Max Delbrueck Center for Molecular Medicine, Berlin-Brandenburg Center for Regenerative Therapies, Berlin, Germany.
Gene. 2012 Apr 10;497(1):10-7. doi: 10.1016/j.gene.2012.01.043. Epub 2012 Jan 30.
The transcription factor CCAAT/enhancer binding protein beta (C/EBPβ) plays a role in the differentiation of a large variety of cell types. C/EBPβ was initially described as an early inducer of adipocyte differentiation, however, recent data have shown that this is not the only mesenchymal cell lineage where C/EBPβ has an instructive function. Mouse models and tissue culture studies have now established a regulatory role of C/EBPβ in osteoblast and in chondrocyte differentiation. These three different cell lineages are derived from the same precursor, the mesenchymal stem cell (MSC). This review will focus on the emerging role of C/EBPβ and its different protein isoforms in various mesenchymal cell lineages and its function in adipocyte, chondrocyte and osteoblast differentiation. Moreover, the mesenchymal stem cell has attracted the attention of regenerative medicine in recent years, and the possible role of C/EBPβ in this respect will be discussed.
转录因子 CCAAT/增强子结合蛋白 β（C/EBPβ）在多种细胞类型的分化中发挥作用。C/EBPβ 最初被描述为脂肪细胞分化的早期诱导因子，然而，最近的数据表明，这并不是 C/EBPβ 具有指导功能的唯一间充质细胞谱系。小鼠模型和组织培养研究现已确立了 C/EBPβ 在成骨细胞和成软骨细胞分化中的调节作用。这三个不同的细胞谱系均来自同一前体细胞，即间充质干细胞（MSC）。本综述将重点介绍 C/EBPβ 及其不同蛋白异构体在各种间充质细胞谱系中的新作用及其在脂肪细胞、软骨细胞和成骨细胞分化中的功能。此外，间充质干细胞近年来引起了再生医学的关注，本文将讨论 C/EBPβ 在这方面的可能作用。
