Division of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA.
Cells. 2019 Oct 5;8(10):1201. doi: 10.3390/cells8101201.
The transfer of adenosine diphosphate (ADP)-ribose unit(s) from nicotinamide adenine dinucleotide (NAD) to acceptor proteins is known as ADP-ribosylation. This post-translational modification (PTM) unavoidably alters protein functions and signaling networks, thereby impacting cell behaviors and tissue outcomes. As a ubiquitous mechanism, ADP-ribosylation affects multiple tissues, including bones, as abnormal ADP-ribosylation compromises bone development and remodeling. In this review, we describe the effects of ADP-ribosylation in bone development and maintenance, and highlight the underlying mechanisms.
将烟酰胺腺嘌呤二核苷酸 (NAD) 上的二磷酸腺苷 (ADP)-核糖单位转移到受体蛋白上的过程被称为 ADP-核糖基化。这种翻译后修饰 (PTM) 不可避免地改变蛋白质的功能和信号网络，从而影响细胞行为和组织结果。作为一种普遍存在的机制，ADP-核糖基化影响包括骨骼在内的多种组织，因为异常的 ADP-核糖基化会损害骨骼的发育和重塑。在这篇综述中，我们描述了 ADP-核糖基化在骨骼发育和维持中的作用，并强调了潜在的机制。
