State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, PR China.
Chem Commun (Camb). 2012 Mar 18;48(23):2909-11. doi: 10.1039/c2cc17468e. Epub 2012 Feb 3.
A practical Pd(PPh(3))(4)/DBU catalytic system for the synthesis of pharmaceutically relevant aminopyridine nitrile intermediates, as well as a variety of other aryl nitriles using non-toxic K(4)[Fe(CN)(6)] has been developed. The key features of our new protocol for cyanation lie in that the reaction can be carried out with readily available Pd(PPh(3))(4) under mild and green conditions, even without the assistance of other ligands.
已开发出一种实用的 Pd(PPh(3))(4)/DBU 催化体系，用于合成具有药用相关性的氨基吡啶腈中间体，以及使用无毒 K(4)[Fe(CN)(6)]合成各种其他芳基腈。我们的氰化新方法的关键特点在于，即使没有其他配体的协助，反应也可以在温和且环保的条件下，使用易得的 Pd(PPh(3))(4)进行。
