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阳性、混合型及阴性精神分裂症综合征中的视觉信息处理

Visual information processing in positive, mixed, and negative schizophrenic syndromes.

作者信息

Weiner R U, Opler L A, Kay S R, Merriam A E, Papouchis N

机构信息

Bustleton Guidance Center, Philadelphia, Pennsylvania.

出版信息

J Nerv Ment Dis. 1990 Oct;178(10):616-26. doi: 10.1097/00005053-199010000-00002.

Abstract

The purpose of this study was to determine whether schizophrenics with positive, mixed, and negative syndromes are distinguished in terms of visual stimulus registration thresholds and efficiency of information processing. Forty-five schizophrenic inpatients were classified accordingly into groups of 15 each and compared with one another and with 15 normal control subjects on a visual backward masking task. Repeated-measures analysis of variance revealed that all three schizophrenic groups were less efficient information processors than were normal subjects. Relative to the positive group, the negative group displayed significantly longer registration thresholds, fewer correct target stimulus detections, and longer time intervals to achieve their first significant improvement in performance and to first exceed chance response levels. The three syndrome groups were not significantly different in their rates of improvement over trials. Secondary correlational analyses showed that the information-processing measures were unrelated to a variety of demographic, psychiatric, and cognitive developmental variables, although shorter recognition thresholds and shorter unmasking interval scores were associated with faster psychomotor rates. Complex interrelationships were uncovered between the information-processing measures, positive and negative symptomatology, and general psychopathology. The results were interpreted as supporting the validity of the positive-negative distinction for explaining some of the heterogeneity in schizophrenia.

摘要

本研究的目的是确定具有阳性、混合型和阴性症状的精神分裂症患者在视觉刺激登记阈值和信息处理效率方面是否存在差异。45名精神分裂症住院患者被相应地分为每组15人的三组,并在视觉反向掩蔽任务中相互比较,同时与15名正常对照受试者进行比较。重复测量方差分析显示,所有三组精神分裂症患者作为信息处理器的效率均低于正常受试者。相对于阳性组,阴性组的登记阈值显著更长,正确检测到的目标刺激更少,并且在表现上首次显著改善以及首次超过随机反应水平所需的时间间隔更长。这三个症状组在试验中的改善率没有显著差异。二次相关分析表明,信息处理指标与各种人口统计学、精神病学和认知发展变量无关,尽管较短的识别阈值和较短的去掩蔽间隔得分与较快的精神运动速度相关。在信息处理指标、阳性和阴性症状以及一般精神病理学之间发现了复杂的相互关系。这些结果被解释为支持阳性-阴性区分对于解释精神分裂症中一些异质性的有效性。

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