Program in Cancer Research, Institut Mar Investigacions Mèdiques, Hospital del Mar, Parc de Recerca Biomèdica de Barcelona, Dr Aiguader 88, Barcelona, Spain.
Blood. 2012 Apr 5;119(14):3226-35. doi: 10.1182/blood-2011-10-355826. Epub 2012 Feb 3.
Notch is a well-conserved signaling pathway and its function in cell fate determination is crucial in embryonic development and in the maintenance of tissue homeostasis during adult life. Notch activation depends on cell-cell interactions that are essential for the generation of cell diversity from initially equivalent cell populations. In the adult hematopoiesis, Notch is undoubtedly a very efficient promoter of T-cell differentiation, and this has masked for a long time the effects of Notch on other blood lineages, which are gradually being identified. However, the adult hematopoietic stem cell (HSC) remains mostly refractory to Notch intervention in experimental systems. In contrast, Notch is essential for the generation of the HSCs, which takes place during embryonic development. This review summarizes the knowledge accumulated in recent years regarding the role of the Notch pathway in the different stages of HSC ontology from embryonic life to fetal and adult bone marrow stem cells. In addition, we briefly examine other systems where Notch regulates specific stem cell capacities, in an attempt to understand how Notch functions in stem cell biology.
Notch 是一条高度保守的信号通路，其在细胞命运决定中的功能对于胚胎发育和成年期组织稳态的维持至关重要。Notch 的激活依赖于细胞间的相互作用，这对于从最初等同的细胞群体中产生细胞多样性是必不可少的。在成人造血中，Notch 无疑是 T 细胞分化的一个非常有效的促进因子，这在很长一段时间内掩盖了 Notch 对其他血液谱系的影响，这些影响正在逐渐被识别。然而，在实验系统中，成年造血干细胞（HSC）对 Notch 干预仍然大多具有抗性。相比之下，Notch 对于胚胎发育过程中 HSCs 的产生是必需的。这篇综述总结了近年来关于 Notch 通路在 HSC 本体论的不同阶段（从胚胎生命到胎儿和成人骨髓干细胞）中的作用的知识。此外，我们还简要地研究了 Notch 调节特定干细胞功能的其他系统，试图了解 Notch 在干细胞生物学中的作用。
