University of Michigan, Ann Arbor, MI, USA.
Adv Exp Med Biol. 2012;727:71-88. doi: 10.1007/978-1-4614-0899-4_6.
Notch signaling exerts multiple important functions in the hematopoietic system. Notch1-mediated signals are essential to induce the onset of definitive hematopoiesis within specialized domains of hemogenic endothelium in the fetal dorsal aorta. In contrast, Notch is dispensable for the subsequent maintenance of hematopoietic stem cells in the adult bone marrow. Notch is a key regulator of early T-cell development in the thymus. An expanding number of hematopoietic and lymphoid cell types have been reported to receive context-dependent inputs from the Notch pathway that regulate their differentiation and function. Progress in the field will continue to bring fundamental information about hematopoiesis and practical insights into the potential to modulate Notch signaling for therapeutic purposes.
Notch 信号通路在造血系统中发挥着多种重要功能。Notch1 介导的信号对于诱导胎儿背主动脉中造血内皮细胞的特定区域中定型造血的发生是必不可少的。相比之下，Notch 在成人骨髓中造血干细胞的后续维持中是可有可无的。Notch 是胸腺中早期 T 细胞发育的关键调节因子。越来越多的造血和淋巴样细胞类型已被报道从 Notch 途径接收依赖于上下文的输入，这些输入调节它们的分化和功能。该领域的进展将继续带来有关造血的基本信息，并深入了解调节 Notch 信号转导以达到治疗目的的潜力。
