Chapel H M, Small M, Gregory S, Matthews W B
Department of Immunology, John Radcliffe Hospital, Oxford, UK.
J Neurol. 1990 Aug;237(5):303-5. doi: 10.1007/BF00314747.
A concurrent change in evoked potential measurements and quantitation of circulating T-suppressor (CD8) lymphocyte subpopulations might indicate increased subclinical disease activity. Eight untreated patients with clinically definite multiple sclerosis were monitored monthly for changes in the numbers of cells positive for CD8 markers, and hence in the ratio of CD4: CD8 positive cells. Such changes were found not to be associated with changes in evoked potentials or clinical status.
诱发电位测量结果与循环中T抑制（CD8）淋巴细胞亚群定量的同时变化，可能表明亚临床疾病活动增加。对8例未经治疗的临床确诊多发性硬化症患者每月监测CD8标记阳性细胞数量的变化，从而监测CD4:CD8阳性细胞的比例变化。结果发现，这些变化与诱发电位或临床状态的变化无关。
