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EBV LMP1: New and shared pathways to NF-κB activation.

作者信息

Lavorgna Alfonso, Harhaj Edward W

机构信息

Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.

出版信息

Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2188-9. doi: 10.1073/pnas.1121357109. Epub 2012 Feb 2.

Abstract
摘要

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Genome-wide siRNA screen for mediators of NF-κB activation.
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The IKK complex, a central regulator of NF-kappaB activation.
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Compensatory IKKalpha activation of classical NF-kappaB signaling during IKKbeta inhibition identified by an RNA interference sensitization screen.
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