EBV LMP1: New and shared pathways to NF-κB activation.
作者信息
Lavorgna Alfonso, Harhaj Edward W
机构信息
Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
出版信息
Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2188-9. doi: 10.1073/pnas.1121357109. Epub 2012 Feb 2.
Abstract
摘要
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Genome-wide siRNA screen for mediators of NF-κB activation.全基因组 siRNA 筛选 NF-κB 激活的介质。
Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2467-72. doi: 10.1073/pnas.1120542109. Epub 2012 Jan 17.
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An RNA interference screen identifies the Deubiquitinase STAMBPL1 as a critical regulator of human T-cell leukemia virus type 1 tax nuclear export and NF-κB activation.RNA 干扰筛选鉴定去泛素化酶 STAMBPL1 为人类 T 细胞白血病病毒 1 型 tax 核输出和 NF-κB 激活的关键调节因子。
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Malignant pirates of the immune system.恶性免疫海盗。
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Deubiquitinases in the regulation of NF-κB signaling.去泛素化酶在 NF-κB 信号转导中的调控作用。
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The IKK complex, a central regulator of NF-kappaB activation.IKK 复合物，NF-κB 激活的核心调节剂。
Cold Spring Harb Perspect Biol. 2010 Mar;2(3):a000158. doi: 10.1101/cshperspect.a000158.
6
IKKalpha and IKKbeta each function to regulate NF-kappaB activation in the TNF-induced/canonical pathway.IKKalpha 和 IKKbeta 各自在 TNF 诱导的/经典途径中发挥作用，以调节 NF-kappaB 的激活。
PLoS One. 2010 Feb 25;5(2):e9428. doi: 10.1371/journal.pone.0009428.
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Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay.Zc3h12a是一种核糖核酸酶，通过调节信使核糖核酸（mRNA）衰变来控制免疫反应，对这一过程至关重要。
Nature. 2009 Apr 30;458(7242):1185-90. doi: 10.1038/nature07924. Epub 2009 Mar 25.
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The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling.泛素编辑酶A20需要RNF11来下调核因子κB信号通路。
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Compensatory IKKalpha activation of classical NF-kappaB signaling during IKKbeta inhibition identified by an RNA interference sensitization screen.通过RNA干扰致敏筛选鉴定出IKKβ抑制期间经典NF-κB信号通路的代偿性IKKα激活。
Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20798-803. doi: 10.1073/pnas.0806491106. Epub 2008 Dec 22.
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Shared principles in NF-kappaB signaling.核因子κB信号传导中的共同原则。
Cell. 2008 Feb 8;132(3):344-62. doi: 10.1016/j.cell.2008.01.020.
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