[复方丹参方主要活性成分的网络药理学研究]
[Network pharmacology study on major active compounds of Fufang Danshen formula].
作者信息
Li Xiang, Wu Leihong, Fan Xiaohui, Zhang Boli, Gao Xiumei, Wang Yi, Cheng Yiyu
机构信息
Department of Chinese Medicine Science & Engineering, Zhejiang University, Hangzhou 310058, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2011 Nov;36(21):2911-5.
OBJECTIVE
To investigate the correlations between multi-compounds of Fufang Danshen formula and their multi targets and multi diseases.
METHOD
Literature knowledge of nine major active compounds from Fufang Danshen formula, including tanshinone II(A), salvianolic acid B, protocatechuic aldehyde, danshensu, cryptotanshinone, notoginsenoside R1, ginsenoside Rg1, ginsenoside Rb1 and borneol were collected from PubMed. Combined with cardiovascular related diseases and genes from OMIM database, the corresponding multi-compound-multi- target-multi-disease network was constructed and visualized by Cytoscape software.
RESULT
AND CONCLUSION: Network analysis showed that the 9 compounds could modulate 42 cardiovascular associated genes (e. g. PPARG, ACE, KCNJ11, KCNQ1, ABCC8, et al), which related to 30 cardiovascular associated diseases including non-insulin-dependent diabetes mellitus, hyperinsulinemic hypoglycemia, hypertension, and coronary heart disease. These results suggested new potential indications of Fufang Danshen formula.
目的
研究复方丹参方多种成分与其多靶点、多疾病之间的相关性。
方法
从PubMed收集复方丹参方9种主要活性成分的文献知识，包括丹参酮IIA、丹酚酸B、原儿茶醛、丹参素、隐丹参酮、三七皂苷R1、人参皂苷Rg1、人参皂苷Rb1和冰片。结合来自OMIM数据库的心血管相关疾病和基因，通过Cytoscape软件构建并可视化相应的多成分-多靶点-多疾病网络。
结果与结论
网络分析表明，这9种化合物可调节42个心血管相关基因（如PPARG、ACE、KCNJ11、KCNQ1、ABCC8等），这些基因与30种心血管相关疾病有关，包括非胰岛素依赖型糖尿病、高胰岛素血症性低血糖症、高血压和冠心病。这些结果提示了复方丹参方新的潜在适应证。
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