TEDA International Cardiovascular Hospital & The Affiliated Hospital of Hangzhou Normal University, Tianjin & Hangzhou, China.
Tianjin Zhongxin Pharmaceutical Group Co., Ltd. No. 6, Traditional Chinese Medicine Factory, Tianjin, China.
Evid Based Complement Alternat Med. 2014;2014:956924. doi: 10.1155/2014/956924. Epub 2014 Apr 7.
Suxiao Jiuxin Pill, a compound Chinese traditional medicine with main components of tetramethylpyrazine and borneol, is widely used for antiangina treatment in China but its pharmacological effect on human blood vessels is unknown. We investigated the effect and possible mechanism of SJP in the human internal mammary artery (IMA, n = 78) taken from patients undergoing coronary surgery. SJP caused full relaxation in KCl- (99.4 ± 10.5%, n = 6) and U46619- (99.9 ± 5.6%, n = 6) contracted IMA. Pretreatment of IMA with plasma concentrations of SJP (1 mg/mL), calculated from the plasma concentration of its major component borneol, significantly depressed the maximal contraction to KCl (from 35.8 ± 6.0 mN to 12.6 ± 5.6 mN, P = 0.03) and U46619 (from 19.4 ± 2.9 mN to 5.7 ± 2.4 mN, P = 0.007) while SJP at 10 mg/mL abolished the subsequent contraction. Endothelium denudation and inhibition of eNOS significantly altered the SJP-induced relaxation without changes of eNOS expression. We conclude that SJP has a potent inhibitory effect on the vasoconstriction mediated by a variety of vasoconstrictors in human arteries. The vasorelaxation involves both endothelium-dependent and -independent mechanisms. Thus, the effect of SJP on human arteries demonstrated in this study may prove to be particularly important in vasorelaxing therapy in cardiovascular disease.
麝香救心丸是一种由川芎嗪和冰片组成的复方中药，在中国被广泛用于抗心绞痛治疗，但它对人体血管的药理作用尚不清楚。我们研究了麝香救心丸对取自行冠状动脉旁路移植术患者的人体内乳动脉（IMA）的作用及其可能机制（n = 78）。麝香救心丸可使 KCl （99.4 ± 10.5%，n = 6）和 U46619 （99.9 ± 5.6%，n = 6）收缩的 IMA 完全松弛。用血浆中冰片的主要成分计算的麝香救心丸（1mg/mL）的血浆浓度预处理 IMA，可显著抑制 KCl （从 35.8 ± 6.0mN 降至 12.6 ± 5.6mN，P = 0.03）和 U46619 （从 19.4 ± 2.9mN 降至 5.7 ± 2.4mN，P = 0.007）引起的最大收缩，而 10mg/mL 的麝香救心丸则消除了随后的收缩。内皮剥脱和 eNOS 抑制显著改变了麝香救心丸引起的舒张反应，但不改变 eNOS 表达。我们的结论是，麝香救心丸对多种血管收缩剂介导的人动脉收缩具有很强的抑制作用。血管舒张作用涉及内皮依赖性和非依赖性机制。因此，本研究中观察到的麝香救心丸对人动脉的作用可能在心血管疾病的血管舒张治疗中特别重要。
