氰基丙烯酸正丁酯胶在大鼠皮下组织中的评价。
Evaluation of n-butyl cyanoacrylate adhesive in rat subcutaneous tissue.
机构信息
Department of Morphology, Dental of School at Araraquara, Araraquara, São Paulo, Brazil.
出版信息
Dermatol Surg. 2012 May;38(5):767-71. doi: 10.1111/j.1524-4725.2011.02278.x. Epub 2012 Feb 6.
BACKGROUND
Tissue adhesives have been widely used for wound closure, especially in children, because they are painless, fast, and easy to use and result in minimal scarring.
OBJECTIVE
To analyze the biocompatibility of an adhesive based on n-butyl-cyanoacrylate in the subcutaneous tissue of rats.
MATERIALS AND METHODS
Two surgical sites were prepared (approximately 3 cm apart): one on the left side of the animal and the other on the right side); polyethylene tubes were implanted in each surgical site. The tube on the left was filled with n-butyl-cyanoacrylate (treated group) and the tube on the right side was unfilled (control group). After 7, 30, and 120 days, the animals were killed, and the specimens were processed for histologic analysis.
RESULTS
No significant inflammatory reaction occurred in the treated group, showing results similar to the control group.
CONCLUSION
This adhesive based on n-butyl-cyanoacrylate is biocompatible in the subcutaneous tissue of rats.
背景
组织粘合剂已被广泛应用于伤口闭合，特别是在儿童中，因为它们无痛、快速、易于使用，并且导致最小的疤痕。
目的
分析一种基于正丁基氰基丙烯酸酯的粘合剂在大鼠皮下组织中的生物相容性。
材料和方法
在动物的左侧和右侧（相距约 3 厘米）准备两个手术部位；在每个手术部位植入聚乙烯管。左侧的管中填充有正丁基氰基丙烯酸酯（处理组），右侧的管中未填充（对照组）。在第 7、30 和 120 天，处死动物，处理标本进行组织学分析。
结果
处理组未发生明显的炎症反应，结果与对照组相似。
结论
这种基于正丁基氰基丙烯酸酯的粘合剂在大鼠的皮下组织中具有生物相容性。
Zotero 插件