治疗性策略以消耗动脉粥样硬化斑块中的巨噬细胞。
Therapeutic strategies to deplete macrophages in atherosclerotic plaques.
机构信息
Division of Physiopharmacology, University of Antwerp, Antwerp, Belgium.
出版信息
Br J Clin Pharmacol. 2012 Aug;74(2):246-63. doi: 10.1111/j.1365-2125.2012.04211.x.
Abstract
Macrophages can be found in all stages of atherosclerosis and are major contributors of atherosclerotic plaque development, progression and destabilization. Continuous recruitment of monocytes drives this chronic inflammatory disease, which can be intervened by several strategies: reducing the inflammatory stimulus by lowering circulating lipids and promoting cholesterol efflux from plaque, direct and indirect targeting of adhesion molecules and chemokines involved in monocyte adhesion and transmigration and inducing macrophage death in atherosclerotic plaques in combination with anti-inflammatory drugs. This review discusses the outlined strategies to deplete macrophages from atherosclerotic plaques to promote plaque stabilization.
摘要
巨噬细胞存在于动脉粥样硬化的各个阶段，是动脉粥样硬化斑块发展、进展和不稳定的主要贡献者。单核细胞的持续募集驱动着这种慢性炎症性疾病，可以通过几种策略进行干预：通过降低循环脂质和促进斑块中胆固醇流出来减少炎症刺激，直接和间接靶向参与单核细胞黏附和迁移的黏附分子和趋化因子，以及联合抗炎药物诱导动脉粥样硬化斑块中巨噬细胞死亡。本文综述了从动脉粥样硬化斑块中耗竭巨噬细胞以促进斑块稳定的策略。
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2
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