Allergy Unit, Centro Cinco Villas, Casar de Salud, Ejea, Zaragoza, Spain.
J Investig Allergol Clin Immunol. 2011;21(7):567-70.
Goji berry (wolfberry), a member of the Solanacea family, has been recently introduced in Western countries and its consumption has increased rapidly. The objectives of the study were to describe the cases of 2 patients who experienced allergic symptoms after Goji berry consumption, to identify the protein profile of the extract, to analyze the allergenic profile of individuals, and to determine cross-reactivity with other members of the Solanaceae family (tomato). We describe 2 cases of allergic reaction, 1 of which was an anaphylactic reaction, after Goji berry ingestion. A Goji berry extract was manufactured and immunochemically characterized. The patients were skin prick tested with a battery of common aeroallergens including mites, epithelia, and molds. Individuals were also skin prick tested with food allergens, including Goji berries. A positive skin prick test and specific immunoglobulin (Ig) E to Goji berry was detected in both cases. Serum samples recognized a 9-kDa band, probably related to lipid transfer proteins (LTPs). Cross-reactivity with tomato was analyzed by inhibition studies, which showed that the 9-kDa band was totally inhibited by the tomato extract. This study describes the first 2 cases of allergic reaction following Goji berry ingestion. LTPs seem to be involved in allergic sensitization to Goji berries, as evidenced by cross-reactivity with tomato.
枸杞（枸杞），茄科的一员，最近在西方国家被引入，其消费迅速增加。本研究的目的是描述 2 例食用枸杞后出现过敏症状的病例，鉴定提取物的蛋白质谱，分析个体的致敏谱，并确定与茄科其他成员（番茄）的交叉反应性。我们描述了 2 例食用枸杞后发生过敏反应的病例，其中 1 例为过敏性反应。枸杞提取物被制造并进行了免疫化学表征。对患者进行了包括螨虫、上皮和霉菌在内的常见气传过敏原的皮肤点刺试验。还对包括枸杞在内的食物过敏原进行了患者的皮肤点刺试验。在这两种情况下均检测到枸杞的阳性皮肤点刺试验和特异性免疫球蛋白（Ig）E。血清样本识别出 9-kDa 带，可能与脂质转移蛋白（LTP）有关。通过抑制研究分析了与番茄的交叉反应性，结果表明番茄提取物完全抑制了 9-kDa 带。本研究描述了食用枸杞后出现的前 2 例过敏反应病例。LTP 似乎参与了枸杞的过敏致敏，这一点可以通过与番茄的交叉反应得到证明。
