Institute of Medical Biology, Genetics and Clinical Genetics, University in Bratislava, Sasinkova 4, 811 08 Bratislava, Slovak Republic.
Exp Biol Med (Maywood). 2012 Jan;237(1):10-7. doi: 10.1258/ebm.2011.011229. Epub 2011 Dec 7.
Damage or loss of articular cartilage as a consequence of congenital anomaly, degenerative joint disease or injury leads to progressive debilitation, which has a negative impact on the quality of life of affected individuals in all age groups. Classical surgical techniques for hyaline cartilage reparation are frequently insufficient and in many cases it is not possible to obtain the expected results. For this reason, researchers and surgeons are forced to find a method to induce complete cartilage repair. Recently, the advent of tissue engineering has provided alternative possibilities for the treatment of these patients by application of cell-based therapy (e.g. chondrocytes and adult stem cells) combined with synthetic substitutes of the extracellular matrix and bioactive factors to prepare functional replacement of hyaline cartilage. This communication is aimed at a brief review of the current status of cartilage tissue engineering and recent advances in the field.
由于先天异常、退行性关节病或损伤导致的关节软骨的损伤或丢失会导致进行性衰弱，这对所有年龄段受影响个体的生活质量都有负面影响。透明软骨修复的经典手术技术常常不够充分，在许多情况下，无法获得预期的结果。出于这个原因，研究人员和外科医生被迫寻找一种方法来诱导完全的软骨修复。最近，组织工程的出现通过应用基于细胞的治疗（例如软骨细胞和成体干细胞）与细胞外基质的合成替代品和生物活性因子相结合，为这些患者的治疗提供了替代可能性，从而为制备透明软骨的功能替代物提供了可能。本通讯旨在简要回顾软骨组织工程的现状和该领域的最新进展。
