Multi-Organ Transplant Program, Dalhousie University, Halifax, Nova Scotia, Canada.
Liver Transpl. 2012 May;18(5):514-23. doi: 10.1002/lt.23408.
The reinfection of the hepatic allograft with hepatitis B virus and hepatitis C virus can have important sequelae that result in poor long-term patient and graft survival. Although a response to treatment with antiviral medications can improve these outcomes, not all patients tolerate these medications or experience viral eradication. Avoiding reinfection of the graft is the most effective means of improving the long-term outcomes for these patient populations. This review is focused on the prevention of viral hepatitis reinfection after liver transplantation.
乙型肝炎病毒和丙型肝炎病毒再次感染肝移植的后果很严重,会导致患者和移植物的长期存活率降低。尽管抗病毒药物治疗可以改善这些结果,但并非所有患者都能耐受这些药物或能实现病毒清除。避免移植物再次感染是改善这些患者群体长期预后的最有效方法。本综述主要探讨肝移植后预防病毒性肝炎再感染。