Bar Ilan University, Ramat Gan, Israel.
Schizophr Res. 2012 May;137(1-3):147-50. doi: 10.1016/j.schres.2012.01.015. Epub 2012 Feb 6.
Increased attention has been given to treatment of negative symptoms and its potential impact on functional outcomes, however previous inferences have been confounded by the fact that measures of functional outcomes often use items similar to those of negative symptoms. We attempted to discern the relative effects of negative symptoms on functioning, as compared to other symptoms, using data from the National Institute of Mental Health CATIE trial of chronic schizophrenia (n=1447) by examining correlations of Positive and Negative Syndrome Scale factors, Calgary Depression Rating Scale and select items from Heinrich's and Lehman's Quality of Life Scales measuring aspects of functioning that did not overlap with negative symptoms. Baseline functioning and change in functioning were more strongly related to PANSS negative factor than any of the other symptoms - though the amount of variance explained by symptom changes in general was small. The data suggests that improvement in negative symptoms may have a distinctive and independent effect on functional outcome relative to other symptoms. This should be further tested in studies where negative symptoms improve without concomitant improvement of other symptoms.
人们越来越关注消极症状的治疗及其对功能结果的潜在影响，然而，由于功能结果的衡量标准通常使用与消极症状相似的项目，以前的推论受到了混淆。我们试图通过检查阳性和阴性综合征量表因子、卡尔加里抑郁评定量表以及 Heinrich 和 Lehman 的生活质量量表中与消极症状不重叠的功能方面的选定项目的相关性，利用国家心理健康研究所慢性精神分裂症 CATIE 试验（n=1447）的数据，来辨别消极症状对功能的相对影响，与其他症状相比。基线功能和功能变化与 PANSS 阴性因子的相关性强于任何其他症状——尽管症状变化总体上解释的方差较小。数据表明，与其他症状相比，消极症状的改善可能对功能结果有独特且独立的影响。这应该在消极症状改善而其他症状没有改善的研究中进一步测试。
