过氧化物酶体增殖物激活受体在癌症发生和化学预防中的作用。
The role of peroxisome proliferator-activated receptors in carcinogenesis and chemoprevention.
机构信息
Department of Veterinary and Biomedical Sciences and The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.
出版信息
Nat Rev Cancer. 2012 Feb 9;12(3):181-95. doi: 10.1038/nrc3214.
Abstract
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that are involved in regulating glucose and lipid homeostasis, inflammation, proliferation and differentiation. Although all of these functions might contribute to the influence of PPARs in carcinogenesis, there is a distinct need for a review of the literature and additional experimentation to determine the potential for targeting PPARs for cancer therapy and cancer chemoprevention. As PPAR agonists include drugs that are used for the treatment of metabolic diseases, a more complete understanding of the roles of PPARs in cancer will aid in determining any increased cancer risk for patients undergoing therapy with PPAR agonists.
摘要
过氧化物酶体增殖物激活受体（PPARs）是配体激活的转录因子，参与调节葡萄糖和脂质稳态、炎症、增殖和分化。尽管所有这些功能都可能影响 PPAR 在癌症发生中的作用，但需要对文献进行综述和进一步的实验，以确定针对 PPAR 进行癌症治疗和癌症化学预防的潜力。由于 PPAR 激动剂包括用于治疗代谢疾病的药物，因此更全面地了解 PPAR 在癌症中的作用将有助于确定接受 PPAR 激动剂治疗的患者的癌症风险是否增加。
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