大鼠肾脏中前列腺素E受体的证据。

Evidence for a PGE-receptor in the rat kidney.

作者信息

Oien H G, Babiarz E M, Soderma D D, Ham E A, Kuehl F A

出版信息

Prostaglandins. 1979 Apr;17(4):525-42. doi: 10.1016/0090-6980(79)90005-4.

Abstract

A membrane preparation derived from homogenates of the rat kidney has been shown to possess a high affinity for prostaglandins of the E-series. Other prostaglandins including PGI2 had characteristic but significantly weaker binding properties. A 15-hydroxyprostaglandin dehydrogenase (PGDH) was found to be associated with the membrane fraction studied. However it was possible to distinguish between this and the "receptor" binding by kinetic studies and by the use of a new inhibitor highly specific for PGDH.

摘要

源自大鼠肾脏匀浆的膜制剂已被证明对E系列前列腺素具有高亲和力。包括前列环素（PGI2）在内的其他前列腺素具有特征性但明显较弱的结合特性。发现15-羟基前列腺素脱氢酶（PGDH）与所研究的膜部分相关。然而，通过动力学研究以及使用对PGDH具有高度特异性的新型抑制剂，可以区分这种结合与“受体”结合。