Roine R, Gentry R T, Hernández-Munõz R, Baraona E, Lieber C S
Section of Liver Diseases and Nutrition and the Alcohol Research and Treatment Center, Bronx Veterans Administration Medical Center, NY 10468.
JAMA. 1990 Nov 14;264(18):2406-8.
Gastric first-pass metabolism of ethanol is an important determinant of blood alcohol concentrations. We studied five healthy volunteers after ingestion of ethanol (0.3 g/kg of body weight) and found that blood alcohol concentrations in the fed state (ie, 1 hour after a standard breakfast) were significantly higher when the subjects received 1 g of aspirin 1 hour before ingestion of ethanol than without the drug. In vitro, aspirin clearly decreased the activity of gastric alcohol dehydrogenase in human subjects and in rat models, but not that of hepatic alcohol dehydrogenase in rats. Furthermore, blood alcohol concentrations in rats were unaffected by ingestion of aspirin when ethanol was infused intravenously. Thus, aspirin may increase the bioavailability of ingested ethanol in humans, possibly by reducing ethanol oxidation by gastric alcohol dehydrogenase.
乙醇的胃首过代谢是血液酒精浓度的一个重要决定因素。我们对五名健康志愿者在摄入乙醇（0.3克/千克体重）后进行了研究，发现当受试者在摄入乙醇前1小时服用1克阿司匹林时，进食状态下（即标准早餐后1小时）的血液酒精浓度显著高于未服用该药物时。在体外，阿司匹林明显降低了人类受试者和大鼠模型中胃乙醇脱氢酶的活性，但对大鼠肝脏乙醇脱氢酶的活性没有影响。此外，当静脉注射乙醇时，大鼠的血液酒精浓度不受阿司匹林摄入的影响。因此，阿司匹林可能会增加人类摄入乙醇的生物利用度，可能是通过减少胃乙醇脱氢酶对乙醇的氧化作用。
