Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
Org Lett. 2012 Feb 17;14(4):1176-9. doi: 10.1021/ol300240k. Epub 2012 Feb 9.
The first example of intermolecular regioselective α-arylation of heteroatom-substituted enones with polyfluoroarenes via twofold C-H bond functionalization using a palladium catalyst is reported. This approach provides rapid access to a wide range of α-fluoroarylated enones of interest in life science.
本文报道了首例钯催化的多氟芳烃与杂原子取代烯酮的分子间区域选择性α-芳基化反应，通过双重 C-H 键功能化反应实现。该方法为生命科学中具有广泛应用前景的α-氟代芳基烯酮提供了快速合成的途径。
