Beijing National Laboratory of Molecular Sciences (BNLMS), College of Chemistry and Green Chemistry Center, Peking University, Beijing 100871, China.
Org Lett. 2011 Jan 21;13(2):276-9. doi: 10.1021/ol102688e. Epub 2010 Dec 20.
The most efficient method to construct biaryls is the direct dehydrogenative cross-coupling of two different aromatic rings. Such an ideal cross arylation starting from distinct polyfluoroarenes and simple arenes was presented. The selectivity of the cross-coupling was controlled by both of the electronic property of fluoroarenes and steric hindrance of simple arenes. Diisopropyl sulfide was essential to promote the efficacy.
构建联芳烃最有效的方法是两种不同芳环的直接脱氢交叉偶联。本文提出了一种从不同的多氟芳烃和简单芳烃出发的理想的交叉芳基化反应。交叉偶联的选择性受氟芳烃的电子性质和简单芳烃的空间位阻的共同控制。二异丙基硫醚对于提高反应效率是必不可少的。
