University of Newcastle, Newcastle, Australia.
Med Phys. 2012 Feb;39(2):623-35. doi: 10.1118/1.3673958.
Electronic portal imaging devices (EPIDs) have been studied and used for pretreatment and in-vivo dosimetry applications for many years. The application of EPIDs for dosimetry in arc treatments requires accurate characterization of the mechanical sag of the EPID and gantry during rotation. Several studies have investigated the effects of gravity on the sag of these systems but each have limitations. In this study, an easy experiment setup and accurate algorithm have been introduced to characterize and correct for the effect of EPID and gantry sag during arc delivery.
Three metallic ball bearings were used as markers in the beam: two of them fixed to the gantry head and the third positioned at the isocenter. EPID images were acquired during a 360° gantry rotation in cine imaging mode. The markers were tracked in EPID images and a robust in-house developed MATLAB code was used to analyse the images and find the EPID sag in three directions as well as the EPID + gantry sag by comparison to the reference gantry zero image. The algorithm results were then tested against independent methods. The method was applied to compare the effect in clockwise and counter clockwise gantry rotations and different source-to-detector distances (SDDs). The results were monitored for one linear accelerator over a course of 15 months and six other linear-accelerators from two treatment centers were also investigated using this method. The generalized shift patterns were derived from the data and used in an image registration algorithm to correct for the effect of the mechanical sag in the system. The Gamma evaluation (3%, 3 mm) technique was used to investigate the improvement in alignment of cine EPID images of a fixed field, by comparing both individual images and the sum of images in a series with the reference gantry zero image.
The mechanical sag during gantry rotation was dependent on the gantry angle and was larger in the in-plane direction, although the patterns were not identical for various linear-accelerators. The reproducibility of measurements was within 0.2 mm over a period of 15 months. The direction of gantry rotation and SDD did not affect the results by more than 0.3 mm. Results of independent tests agreed with the algorithm within the accuracy of the measurement tools. When comparing summed images, the percentage of points with Gamma index <1 increased from 85.4% to 94.1% after correcting for the EPID sag, and to 99.3% after correction for gantry + EPID sag.
The measurement method and algorithms introduced in this study use cine-images, are highly accurate, simple, fast, and reproducible. It tests all gantry angles and provides a suitable automatic analysis and correction tool to improve EPID dosimetry and perform comprehensive linac QA for arc treatments.
电子射野影像装置(EPID)已经研究和应用于治疗前和体内剂量学多年。EPID 用于弧形治疗的剂量学应用需要准确地描述 EPID 和机架在旋转过程中的机械下垂。已有多项研究调查了重力对这些系统下垂的影响,但每项研究都存在局限性。在这项研究中,引入了一种简单的实验设置和准确的算法,以描述和校正弧形传输过程中 EPID 和机架下垂的影响。
在射束中使用三个金属滚珠作为标记:两个固定在机架头上,第三个位于等中心。在 cine 成像模式下,采集 360°机架旋转时的 EPID 图像。在 EPID 图像中跟踪标记,并使用内部开发的强大 MATLAB 代码分析图像,以找到三个方向上的 EPID 下垂以及通过与参考机架零图像比较得出的 EPID+机架下垂。然后,将算法结果与独立方法进行测试。该方法用于比较顺时针和逆时针机架旋转以及不同源到探测器距离(SDD)的影响。在 15 个月的时间里对一台直线加速器进行了监测,还使用该方法研究了来自两个治疗中心的另外六台直线加速器。从数据中推导出广义移位模式,并将其用于图像配准算法中,以校正系统中的机械下垂影响。使用伽玛评估(3%,3mm)技术通过比较固定野 cine EPID 图像的单个图像和一系列图像的总和与参考机架零图像,来研究图像对齐的改善。
机架旋转过程中的机械下垂取决于机架角度,在平面内方向较大,尽管不同直线加速器的模式并不完全相同。在 15 个月的时间里,测量的重复性在 0.2mm 以内。机架旋转方向和 SDD 的影响不超过 0.3mm。独立测试的结果与测量工具的精度内的算法一致。在比较总和图像时,校正 EPID 下垂后,伽玛指数<1的点的百分比从 85.4%增加到 94.1%,校正 EPID+机架下垂后增加到 99.3%。
本研究中引入的测量方法和算法使用 cine 图像,具有高度精确、简单、快速和可重复性。它测试了所有机架角度,并提供了一种合适的自动分析和校正工具,以改善 EPID 剂量学并对弧形治疗进行全面的直线加速器 QA。