Rostami Aram, Barzegar Mojtaba, Usman Muhammad, Paloor Satheesh Prasad, Mkanna Abbass Yousef, Al-Sabahi Alla Fuad, Hammoud Rabih Wafiq
Radiation Oncology Department, National Center for Cancer Care and Research, Doha, Qatar.
Society for Brain Mapping and Therapeutic, Los Angles, California, USA.
J Appl Clin Med Phys. 2024 Dec;25(12):e14523. doi: 10.1002/acm2.14523. Epub 2024 Sep 11.
This study investigates the influence of gantry and collimator angles on the dosimetric leaf gap (DLG) and leaf transmission factor (LTF) in a Varian LINAC equipped with rounded-end multi-leaf collimators (MLCs). While Varian guidelines recommend DLG measurements at zero degrees for both gantry and collimator, this research aims to address the knowledge gap by assessing DLG and LTF variations at different gantry and collimator angles.
Measurements were conducted using a Varian TrueBeam LINAC with a Millennium 120-leaf MLC and Eclipse TPS version 16.1. The beams utilized in this study had energies of 6 MV, 10 MV, 6 FFF, and 10 FFF. LTF and DLG were determined using ionization chambers in solid water phantoms at various gantry angles (0°, 45°, 90°, 135°, 180°, 225°, 270°, and 315°). For each gantry angle, measurements were also taken at various collimator angles (0°, 45°, 90°, and 315°). Dosimetric impacts were evaluated through VMAT Picket Fence tests and patient-specific verification using portal dosimetry for 10 clinical VMAT plans.
LTF values showed no significant variation across gantry and collimator angles. However, DLG values exhibited notable differences depending on the gantry angle and were independent of the collimator angle. The highest DLG value was observed at a gantry angle of 270 degrees, while the lowest was at 90 degrees. The AXB DLG (averaging seven measurements of DLGs at different gantry angles) model demonstrated the best agreement between measured and calculated dose distributions, indicating the importance of considering averaged DLG values across multiple gantry angles for accurate dose calculations.
Our study highlights the variability of DLG with gantry angle alterations, contrary to Varian guidelines recommending DLG measurements at zero gantry angle only. We advocate for utilizing an averaged DLG value from measurements across multiple gantry angles, as outlined in our methodology.
本研究调查了配备圆头多叶准直器(MLC)的瓦里安直线加速器中机架角度和准直器角度对剂量学叶片间隙(DLG)和叶片透射因子(LTF)的影响。虽然瓦里安指南建议在机架和准直器均为零度时测量DLG,但本研究旨在通过评估不同机架和准直器角度下的DLG和LTF变化来填补这一知识空白。
使用配备Millennium 120叶MLC的瓦里安TrueBeam直线加速器和Eclipse TPS版本16.1进行测量。本研究中使用的射束能量为6 MV、10 MV、6 FFF和10 FFF。在固体水模体中,使用电离室在不同机架角度(0°、45°、90°、135°、180°、225°、270°和315°)下测定LTF和DLG。对于每个机架角度,还在不同准直器角度(0°、45°、90°和315°)下进行测量。通过容积调强弧形治疗(VMAT)栅栏测试和使用10个临床VMAT计划的射野剂量学进行患者特异性验证来评估剂量学影响。
LTF值在机架和准直器角度之间没有显著变化。然而,DLG值根据机架角度表现出显著差异,且与准直器角度无关。在机架角度为270度时观察到最高的DLG值,而在90度时最低。AXB DLG(对不同机架角度下的DLG进行七次测量的平均值)模型在测量和计算的剂量分布之间显示出最佳一致性,表明在准确剂量计算中考虑多个机架角度的平均DLG值的重要性。
我们的研究突出了DLG随机架角度变化的可变性,这与瓦里安指南仅建议在机架角度为零时测量DLG相反。我们主张按照我们方法中所述,使用多个机架角度测量的平均DLG值。