HOGG1 Ser326Cys 多态性与肺癌易感性的关联：基于 22475 例的荟萃分析。
Association between the hOGG1 Ser326Cys polymorphism and lung cancer susceptibility: a meta-analysis based on 22,475 subjects.
机构信息
Department of Oncology, Shengjing Hospital Affiliated to China Medical University, Shenyang 110003, China.
出版信息
Diagn Pathol. 2013 Aug 23;8:144. doi: 10.1186/1746-1596-8-144.
OBJECTIVES
The Ser326Cys polymorphism in the human 8-oxogunaine glycosylase (hOGG1) gene with lung cancer susceptibility had been investigated, but results were inconsistent and underpowered. The aim of this study was to conduct a meta-analysis assessing the association of hOGG1 Ser326Cys polymorphism with risk of lung cancer.
MATERIALS AND METHODS
Relevant studies were identified through a search of MEDLINE, PubMed, Web of Science, EMBASE, and Chinese Biomedical Literature database (CBM) using terms "lung cancer", "hOGG1" or "OGG1", "polymorphism" or "variation" and the last search updated on May 1, 2013. In this meta-analysis, we assessed 30 published studies involving 22,475 subjects that investigated the association between the hOGG1 Ser326Cys polymorphism and lung cancer susceptibility.
RESULTS
Overall, the hOGG1 Ser326Cys polymorphism was not associated with lung cancer susceptibility in different genetic models (dominant model comparison: OR = 0.133; 95% CI = 0.111-0.161; P(heterogeneity) = 0.000), and recessive model: OR = 0.543; 95% CI = 0.399-0.739; P(heterogeneity) = 0.000). Similarly, in the stratified analyses by ethnicity, significantly increased risks were found among Asians for homozygote comparison (OR = 0.850; 95% CI = 0.732 0.986; P(heterogeneity) = 0.064), and dominant model (OR = 0.160; 95% CI = 0.137-0.187; P(heterogeneity) = 0.001), and Caucasians for dominant model (OR = 1.35; 95% CI = 1.03-1.77; P(heterogeneity) = 0.015), and recessive model (OR = 1.35; 95% CI = 1.03-1.77; P(heterogeneity) = 0.015). In population-based populations, marginally significant increased risks were found in dominant model (OR = 0.143; 95% CI = 0.111 0.184; P(heterogeneity) = 0.000) and recessive model (OR = 0.429; 95% CI = 0.261-0.705; P(heterogeneity) = 0.000). We also found a significant difference between hOGG1 Ser326Cys genotype and lung cancer susceptibility in studies with hospital-based controls for homozygote model (OR = 0.798; 95% CI = 0.649-0.982; P(heterogeneity )= 0.007),dominant model (OR = 0.122; 95% CI = 0.091-0.163; P(heterogeneity) = 0.000).
CONCLUSION
Our data showed that the hOGG1 Ser326Cys polymorphism contributed to the risk of lung cancer.
VIRTUAL SLIDES
The virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/3842531131031605.
目的
人类 8-氧鸟嘌呤糖苷酶（hOGG1）基因 Ser326Cys 多态性与肺癌易感性的关系已经得到了研究，但是结果不一致且统计效能不足。本研究的目的是进行荟萃分析，评估 hOGG1 Ser326Cys 多态性与肺癌风险的相关性。
材料与方法
通过检索 MEDLINE、PubMed、Web of Science、EMBASE 和中国生物医学文献数据库（CBM），使用“肺癌”、“hOGG1”或“OGG1”、“多态性”或“变异”等术语，对截至 2013 年 5 月 1 日的相关研究进行了搜索。在这项荟萃分析中，我们评估了 30 项已发表的研究，这些研究共涉及 22475 名受试者，调查了 hOGG1 Ser326Cys 多态性与肺癌易感性之间的关系。
结果
总体而言，不同遗传模型（显性模型比较：OR = 0.133；95%CI = 0.111-0.161；P（异质性）= 0.000）和隐性模型（OR = 0.543；95%CI = 0.399-0.739；P（异质性）= 0.000）中，hOGG1 Ser326Cys 多态性与肺癌易感性均无相关性。同样，在按种族进行的分层分析中，亚洲人群的同合子比较（OR = 0.850；95%CI = 0.732-0.986；P（异质性）= 0.064）和显性模型（OR = 0.160；95%CI = 0.137-0.187；P（异质性）= 0.001）中，以及高加索人群的显性模型（OR = 1.35；95%CI = 1.03-1.77；P（异质性）= 0.015）和隐性模型（OR = 1.35；95%CI = 1.03-1.77；P（异质性）= 0.015）中，风险均显著增加。在基于人群的人群中，显性模型（OR = 0.143；95%CI = 0.111-0.184；P（异质性）= 0.000）和隐性模型（OR = 0.429；95%CI = 0.261-0.705；P（异质性）= 0.000）中，风险也有显著增加的趋势。我们还发现，在基于医院的对照研究中，hOGG1 Ser326Cys 基因型与肺癌易感性在同合子模型（OR = 0.798；95%CI = 0.649-0.982；P（异质性）= 0.007）和显性模型（OR = 0.122；95%CI = 0.091-0.163；P（异质性）= 0.000）中存在显著差异。
结论
我们的数据表明，hOGG1 Ser326Cys 多态性与肺癌的风险有关。
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