Wang Fu-Bin, Yang Xue-Qin, Yang Shuo, Wang Bi-Cheng, Feng Mao-Hui, Tu Jian-Cheng
Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
Asian Pac J Cancer Prev. 2011;12(10):2629-35.
The prevalence of prostate cancer (PCa) is high and PCa is the most common cutaneous cancer in men worldwide. Despite extensive research efforts, very few biomarkers of PCa have been introduced to date in clinical practice. A meta-analysis was performed on the most recently reported CTC to assess its prognostic effect and to elucidate whether its detection in the peripheral blood of patients diagnosed with metastatic, castration-resistant prostate cancer (CPRC) and Hormone Refractory Prostate Cancer (HRPC) can be used as a prognostic factor for survival.
We searched Science Direct, EMBASE, PubMed, and Cell Research databases for studies that assessed the prognostic relevance of the presence number of circulating tumor cells (CTC) detection in the peripheral blood (PB). A fixed effects model with relative risk (RR) and 95% confidence interval (95% CI) is used for analysis.
A total of 4 studies, including 486 patients, were eligible for final analysis. Pooled analysis indicated the presence number of CTC per 7.5 ml peripheral blood is associated with a poor survival rate (RR=2.51, 95% CI 1.96-3.21).
The unfavorable count (presence of 5 or more CTCs per 7.5 ml peripheral blood) was associated with poor overall survival in patients with PCa. CTC counts can be used as an accurate and independent predictor of survival rate in patients with PCa.
前列腺癌（PCa）的患病率很高，是全球男性中最常见的皮肤癌。尽管进行了广泛的研究，但迄今为止，在临床实践中引入的PCa生物标志物很少。对最近报道的循环肿瘤细胞（CTC）进行荟萃分析，以评估其预后效果，并阐明在诊断为转移性去势抵抗性前列腺癌（CPRC）和激素难治性前列腺癌（HRPC）的患者外周血中检测到的CTC是否可作为生存的预后因素。
我们在Science Direct、EMBASE、PubMed和Cell Research数据库中搜索了评估外周血（PB）中循环肿瘤细胞（CTC）检测数量的预后相关性的研究。采用相对风险（RR）和95%置信区间（95%CI）的固定效应模型进行分析。
共有4项研究，包括486例患者，符合最终分析的条件。汇总分析表明，每7.5ml外周血中CTC的数量与较差的生存率相关（RR=2.51，95%CI 1.96-3.21）。
不利计数（每7.5ml外周血中存在5个或更多CTC）与PCa患者的总体生存率较差相关。CTC计数可作为PCa患者生存率的准确且独立的预测指标。
