Cornea Research Chair, Department of Optometry and Vision Sciences, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, Riyadh 11433, Saudi Arabia.
Cont Lens Anterior Eye. 2012 Jun;35(3):118-28. doi: 10.1016/j.clae.2012.01.002. Epub 2012 Feb 10.
To quantify the influence of soft contact lens power and thickness on the intraocular pressure (IOP).
Thirty-nine young, healthy adult volunteers completed this study. One eye of each subject was randomly assigned either a +6D or a -6D high water content daily disposable lens. The other eye was fitted with the second lens. Triplicate measurements of IOP were taken before, during, and after contact lens wear. Each time, IOP was assessed in a randomized order with two noncontact tonometers. The lenses were swapped between eyes during a second session of measurements, one week later.
In the first session with the +6D lenses, the average IOPs (±SDs) before, with the lenses fitted, and after the lenses were removed, were: 14.3 ± 2.9 mmHg, 17.0 ± 3.3 mmHg and 13.9 ± 3.1 mmHg, respectively, for the CT80 and 13.6 ± 3.1 mmHg, 17.1 ± 4.5 mmHg and 13.3 ± 2.9 mmHg, respectively, for the PT100. The corresponding values for the first session with the -6D lenses were: 14.3 ± 3.1 mmHg, 13.1 ± 3.1 mmHg and 14.1 ± 3.3 mmHg, respectively, for the CT80 and 13.6 ± 3.2 mmHg, 13.0 ± 3.0 mmHg and 13.6 ± 3.2 mmHg, respectively, for the PT100. IOP significantly (P<0.05) increased (+ΔIOP=2.7 ± 0.4 mmHg with the CT80 in the first session) with the +6D lenses, but decreased (P<0.05) when the -6D lenses were fitted (-ΔIOP=0.6 ± 0.2 mmHg with the PT100 in the first session). The soft contact lens-induced changes were consistent between sessions but varied between tonometers.
The measurement of IOP through soft contact lenses resulted in consistent, statistically significant differences in IOP, which were not uniform across tonometers and which did not appear to be solely related to the central thickness of the soft contact lenses.
定量研究软性亲水接触镜屈光度和厚度对眼内压（IOP）的影响。
39 名健康的年轻成年志愿者参与了本研究。每位志愿者的每只眼随机佩戴+6D 或-6D 高含水量日戴型软性亲水接触镜。另一只眼则佩戴第二副镜片。接触镜佩戴前后，用两种非接触眼压计重复测量 3 次IOP。每次测量时，IOP 以随机顺序进行评估。在第一阶段佩戴+6D 镜片时，使用 CT80 测量的平均值（±SD）为：戴镜前 14.3 ± 2.9mmHg，戴镜时 17.0 ± 3.3mmHg，摘镜后 13.9 ± 3.1mmHg；使用 PT100 测量的平均值为：戴镜前 14.3 ± 3.1mmHg，戴镜时 17.1 ± 4.5mmHg，摘镜后 13.3 ± 2.9mmHg。第一阶段佩戴-6D 镜片时，使用 CT80 测量的平均值为：戴镜前 14.3 ± 3.1mmHg，戴镜时 13.1 ± 3.1mmHg，摘镜后 14.1 ± 3.3mmHg；使用 PT100 测量的平均值为：戴镜前 13.6 ± 3.2mmHg，戴镜时 13.0 ± 3.0mmHg，摘镜后 13.6 ± 3.2mmHg。与佩戴-6D 镜片相比，+6D 镜片（第一阶段使用 CT80 测量时，IOP 升高了+ΔIOP=2.7 ± 0.4mmHg）可显著升高 IOP（P<0.05），而-6D 镜片（第一阶段使用 PT100 测量时，IOP 降低了-ΔIOP=0.6 ± 0.2mmHg）则可显著降低 IOP（P<0.05）。接触镜引起的变化在两个阶段之间是一致的，但在两种眼压计之间存在差异。
通过软性亲水接触镜测量 IOP 可导致 IOP 出现一致的、具有统计学意义的差异，且这种差异在眼压计之间并不均匀，似乎与软性亲水接触镜的中心厚度无关。
