Koshino Y, Takai T, Kato T, Moriwaki H, Muto Y, Shikano Y, Maeda M, Mori S
First Department of Internal Medicine, Gifu University School of Medicine, Japan.
Gastroenterol Jpn. 1991 Oct;26(5):575-81. doi: 10.1007/BF02781672.
A study was conducted to elucidate the relation between the severity of progressive systemic sclerosis (PSS) and the grade of esophageal function disorder, the extent of which was estimated using esophageal manometry. Fifty two patients with PSS were divided into the mild, moderate and severe groups according to the severity score established by the PSS Research Group supported by The Ministry of Health and Welfare of Japan. Primary peristaltic pressure in the esophageal body at 25 to 35cm from the incisors as well as lower esophageal sphincter pressure (LESP), which represents the function of the smooth muscle of the esophagus, were significantly decreased in parallel with the increasing severity of PSS. In contrast, there was no significant difference in upper esophageal sphincter pressure (UESP) or in primary peristaltic pressure at 20cm from the incisors, indicating that the function of striated muscle of the esophagus was not impaired. In addition, even in the mild PSS group without dysphagia (19 cases), primary peristaltic pressure in the esophageal body at 25 to 35cm from incisors was found to be significantly decreased in comparison with the control. Hence, esophageal manometry was useful for early detection of the pathophysiological state of the esophageal function in PSS.
一项研究旨在阐明进行性系统性硬化症（PSS）的严重程度与食管功能障碍程度之间的关系，食管功能障碍程度通过食管测压来评估。52例PSS患者根据日本厚生省支持的PSS研究组制定的严重程度评分分为轻度、中度和重度组。随着PSS严重程度的增加，距切牙25至35厘米处食管体的原发性蠕动压力以及代表食管平滑肌功能的食管下括约肌压力（LESP）均显著降低。相比之下，食管上括约肌压力（UESP）或距切牙20厘米处的原发性蠕动压力没有显著差异，这表明食管横纹肌的功能没有受损。此外，即使在无吞咽困难的轻度PSS组（19例）中，距切牙25至35厘米处食管体的原发性蠕动压力与对照组相比也显著降低。因此，食管测压有助于早期发现PSS患者食管功能的病理生理状态。
