准备好要分开了。
Fixin' to divide.
机构信息
David H. Koch Institute for Integrative Cancer Research, Departments of Biology and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
出版信息
Mol Cell. 2012 Feb 10;45(3):273-5. doi: 10.1016/j.molcel.2012.01.022.
Abstract
In this issue of Molecular Cell, Yata et al. (2012) show that the mitotic kinase and cell-cycle regulator Plk1 can directly stimulate the DNA repair process, providing a potential mechanism of crosstalk between DNA repair and cell-cycle signaling.
摘要
在本期《分子细胞》中，Yata 等人（2012 年）表明，有丝分裂激酶和细胞周期调节剂 Plk1 可以直接刺激 DNA 修复过程，为 DNA 修复和细胞周期信号之间的串扰提供了一个潜在的机制。
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本文引用的文献
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Plk1 and CK2 act in concert to regulate Rad51 during DNA double strand break repair.Plk1 和 CK2 协同作用调节 DNA 双链断裂修复过程中的 Rad51。
Mol Cell. 2012 Feb 10;45(3):371-83. doi: 10.1016/j.molcel.2011.12.028.
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Inhibition of homologous recombination by the PCNA-interacting protein PARI.PCNA 相互作用蛋白 PARI 抑制同源重组。
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Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis.有丝分裂同源重组维持基因组稳定性并抑制肿瘤发生。
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A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint.一个有丝分裂磷酸化反馈网络将 Cdk1、Plk1、53BP1 和 Chk2 连接起来，使 G(2)/M DNA 损伤检查点失活。
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A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage.一种超模块 FHA/BRCT 重复结构介导 Nbs1 衔接蛋白在 DNA 损伤应答中的功能。
Cell. 2009 Oct 2;139(1):100-11. doi: 10.1016/j.cell.2009.07.043.
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Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair.Nbs1灵活地连接Ctp1和Mre11-Rad50，以协调DNA双链断裂的处理和修复。
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Human CtIP promotes DNA end resection.人类CtIP蛋白促进DNA末端切除。
Nature. 2007 Nov 22;450(7169):509-14. doi: 10.1038/nature06337. Epub 2007 Oct 28.
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Getting in and out of mitosis with Polo-like kinase-1.通过Polo样激酶-1进出有丝分裂
Oncogene. 2005 Apr 18;24(17):2844-59. doi: 10.1038/sj.onc.1208617.
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Full-length archaeal Rad51 structure and mutants: mechanisms for RAD51 assembly and control by BRCA2.全长古菌Rad51结构与突变体：BRCA2介导RAD51组装与调控的机制
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