肝内胆管癌的腺瘤-癌序列
Adenoma-carcinoma sequence in intrahepatic cholangiocarcinoma.
作者信息
Pinho André Costa, Melo Renato Bessa, Oliveira Manuel, Almeida Marinho, Lopes Joanne, Graça Luís, Costa-Maia J
机构信息
Hepatobiliary-pancreatic Unit, General Surgery Department, Hospital S. João, Alameda Prof. Hernâni Monteiro 4200-319, Portugal; Faculty of Medicine, University of Porto, Hospital S. João, Alameda Prof. Hernâni Monteiro 4200-319, Portugal.
出版信息
Int J Surg Case Rep. 2012;3(4):131-3. doi: 10.1016/j.ijscr.2012.01.002. Epub 2012 Jan 18.
INTRODUCTION
Cholangiocarcinoma is a rare tumor but recent data report a worldwide increase in incidence and mortality. There are several risk factors associated with cholangiocarcinoma, and chronic inflammation of billiary tree seems to be implied in the cholangiocarcinogenesis, but little is known about this process.
PRESENTATION OF CASE
We present a 56-year-old female with a bile duct adenoma incidentally discovered in the follow up of breast cancer that 18 months later progress to intrahepatic cholangiocarcinoma.
DISCUSSION
This is a rare presentation of intrahepatic cholangiocarcinoma that suggests the classic adenoma-carcinoma sequence in cholangiocarcinogenesis. Furthermore this case gives rise to some questions about the possible common ground on intrahepatic cholangiocarcinoma and breast cancer.
CONCLUSION
Cholangiocarcinogenesis is a complex multi-step mechanism and further investigations are needed to fully understand this process.
引言
胆管癌是一种罕见的肿瘤，但近期数据显示其在全球范围内的发病率和死亡率都有所上升。胆管癌存在多种风险因素，胆管树的慢性炎症似乎与胆管癌发生有关，但对此过程了解甚少。
病例介绍
我们报告一名56岁女性，在乳腺癌随访中偶然发现胆管腺瘤，18个月后进展为肝内胆管癌。
讨论
这是肝内胆管癌的一种罕见表现，提示胆管癌发生存在经典的腺瘤-癌序列。此外，该病例引发了一些关于肝内胆管癌和乳腺癌可能共同基础的问题。
结论
胆管癌发生是一个复杂的多步骤机制，需要进一步研究以充分了解这一过程。
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