Poca Maria Antonia, Galard Rosa, Serrano Elena, Merino Mari Angels, Pozo-Rosich Patricia, Solana Elisabeth, Mestres Olga, de la Calzada Maria Dolores, Sahuquillo Juan
Department of Neurosurgery, Universitat Autònoma de Barcelona, Barcelona, Spain.
Acta Neurochir Suppl. 2012;114:221-5. doi: 10.1007/978-3-7091-0956-4_43.
Low levels of hypocretin-1 (HC-1) have been associated with hypersomnia, obesity, depression, and chronic headaches. These conditions are frequently present in patients with idiopathic intracranial hypertension (IIH) and may be associated with abnormalities of the hypocretin system. The aim of this study was to determine HC-1 concentrations in cerebrospinal fluid (CSF) in a series of patients with IIH and to compare these concentrations with those in a control group with no neurological alterations.
This prospective study included a cohort of 26 consecutive patients with IIH who were mostly women (25 vs. 1) with a mean age of 42.5 ± 13.2. CSF samples were obtained from a lumbar puncture performed between 08:00 and 10:00 a.m. HC-1 was determined by a competitive radioimmunoassay (RIA) using I(125) as the isotope. Samples of normal CSF were obtained during spinal anesthesia for urological, general or vascular surgery from 40 patients (10 women and 30 men with a mean age of 63.7 ± 14.8) with no previous neurological or psychiatric history, a normal neurological examination, and MMSE scores of ≥ 24.
No statistically significant differences were found between HC-1 levels in the CSF of patients with IIH (119.61 ± 21.63 pg/mL) and those of the control group (119.07 ± 20.30 pg/mL; p = 0.918).
HC-1 is not associated with the clinical symptoms present in patients with IIH.
低水平的食欲素-1（HC-1）与发作性睡病、肥胖、抑郁及慢性头痛有关。这些情况在特发性颅内高压（IIH）患者中很常见，可能与食欲素系统异常有关。本研究的目的是测定一系列IIH患者脑脊液（CSF）中的HC-1浓度，并将这些浓度与无神经功能改变的对照组进行比较。
这项前瞻性研究纳入了连续26例IIH患者，大多数为女性（25例对1例），平均年龄42.5±13.2岁。脑脊液样本于上午8:00至10:00之间通过腰椎穿刺获取。HC-1采用以I(125)为同位素的竞争性放射免疫分析（RIA）进行测定。正常脑脊液样本取自40例泌尿外科、普通外科或血管外科手术行脊髓麻醉的患者（10例女性和30例男性，平均年龄63.7±14.8岁），这些患者既往无神经或精神病史，神经系统检查正常，简易精神状态检查表（MMSE）评分≥24分。
IIH患者脑脊液中的HC-1水平（119.61±21.63 pg/mL）与对照组（119.07±20.30 pg/mL；p = 0.918）之间未发现统计学显著差异。
HC-1与IIH患者的临床症状无关。
