Tsvetkov P, Petkova K, Kharalambiev Kh
Vet Med Nauki. 1978;15(9):21-7.
Obtained are two types of hyperimmune sera against the virus of the mucous disease--viral diarrhea (MD--VD) by means of subcutaneous and venous hyperimmunization of cattle with a live viral suspension: (a) A polyvariant hyperimmune serum, obtained by the use of four local and reference strains of the MD--VD virus with a neutralization titre against the Nadl strain of 1 : 1280. (b) Monovariant hyperimmune serum, prepared by the use of a reference strain of the MD--VD virus with a neutralization titre against the Nadl strain of 1 : 1280. On testing experimental calves and application in practice, it has not been established that the polyvariant serum possesses a marked protective effect at a dose of 1 cm3/kg.
通过用活病毒悬液对牛进行皮下和静脉超免疫，获得了两种抗黏液病病毒——病毒性腹泻（MD-VD）的超免疫血清：（a）一种多价超免疫血清，使用MD-VD病毒的四种本地和参考菌株获得，对Nadl菌株的中和效价为1:1280。（b）单价超免疫血清，使用MD-VD病毒的一种参考菌株制备，对Nadl菌株的中和效价为1:1280。在对实验小牛进行测试并在实践中应用时，尚未确定多价血清在1 cm³/kg的剂量下具有显著的保护作用。
