Department of Physiology, Zlotowski Center for Neuroscience, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Glia. 2012 May;60(6):843-50. doi: 10.1002/glia.22286. Epub 2012 Feb 10.
The role of zinc in neurobiology has been the subject of intense interest particularly because of zinc's presence in and release from glutamatergic synapses, and its association with major neurological disorders. Initially considered inert to Zn(2+) signaling and resistant to Zn(2+) toxicity, glia, like neurons, is now known to be vulnerable to Zn(2+) , albeit to a lesser degree and in ways that are type-specific. The discovery of Zn(2+) transporters and the development of highly sensitive zinc sensors has led to a new understanding regarding the role of this metal ion in glial physiology. Dynamic changes in Zn(2+) content are now linked to executive functions, signaling and fate in glia. In this review, we focus on these issues and discuss the broader implication of glial Zn(2+) signaling in neuron glial-interactions.
锌在神经生物学中的作用一直是人们关注的焦点，特别是因为锌存在于谷氨酸能突触中并从中释放，以及它与主要神经疾病的关联。最初被认为对 Zn(2+)信号无作用且对 Zn(2+)毒性有抗性，胶质细胞与神经元一样，现在已知易受 Zn(2+)的影响，尽管程度较轻，且方式具有特异性。Zn(2+)转运体的发现和高灵敏度锌传感器的开发，使人们对这种金属离子在神经胶质生理学中的作用有了新的认识。Zn(2+)含量的动态变化与胶质细胞的执行功能、信号转导和命运有关。在这篇综述中，我们关注这些问题，并讨论胶质细胞 Zn(2+)信号在神经元-胶质细胞相互作用中的更广泛意义。
