Carnevale N T, Woolf T B, Shepherd G M
Neurology Department, SUNY, Stony Brook 11794.
J Neurosci Methods. 1990 Aug;33(2-3):135-48. doi: 10.1016/0165-0270(90)90017-a.
Computational models can provide critical tests of hypotheses of neuronal function. These models are essential for dealing with the complications of time- and voltage-dependent (active) ionic conductances. Commercial circuit analysis programs have been useful tools for this work. We report our experience modelling biophysically realistic membrane properties with SABER (Analogy, Inc.), a new general purpose simulator. SABER allows construction of models with arbitrary membrane properties. This is a major advantage over similar programs (e.g. SPICE), which are limited to a predefined library of electronic components. The empirically determined equations that describe rate constants, ionic conductances, currents, and concentration shifts can be translated directly into model elements ('templates') written in C-like code. We describe the development of SABER models that simulate a synapse and an action potential.
计算模型能够对神经元功能的假设进行关键检验。这些模型对于处理时间和电压依赖性（主动）离子电导的复杂性至关重要。商业电路分析程序一直是这项工作的有用工具。我们报告了使用新型通用模拟器SABER（Analogy公司）对生物物理逼真的膜特性进行建模的经验。SABER允许构建具有任意膜特性的模型。这是相对于类似程序（如SPICE）的一个主要优势，后者仅限于预定义的电子元件库。描述速率常数、离子电导、电流和浓度变化的经验确定方程可以直接转换为用类C代码编写的模型元素（“模板”）。我们描述了模拟突触和动作电位的SABER模型的开发。
