Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, Canada.
Otolaryngol Head Neck Surg. 2012 Jul;147(1):74-8. doi: 10.1177/0194599812437332. Epub 2012 Feb 10.
The objective of this study was to investigate the changes in the epidemiology (incidence, age at diagnosis, and survival) of head and neck cancers (HNCs) in Canada in the past decade.
Analysis of a national cancer data registry.
All Canadian hospital institutions treating head and neck cancer.
Using Canadian Cancer Registry data (1992-2007), the authors categorized HNCs into 3 groups according to their possible association with human papillomavirus (HPV): oropharynx (highly associated), oral cavity (moderate association), and "other" (hypopharynx, larynx, and nasopharynx), which are not HPV related. They calculated age-adjusted incidence, median age at diagnosis, and survival for each category.
Oropharynx tumors increased in incidence over the study time period (annual percent change: 1.50% men, 0.8% women), whereas oral cavity tumors decreased (2.10% men, 0.4% women), as did other HNCs (decreased by 3.0% for men and 1.9% for women). The median age at diagnosis for oropharynx cancer decreased by an average of 0.23 years/y. There was no change for oral cavity tumors but an increase for other HNCs of 0.12 years/y. Survival for patients with oropharynx cancer increased by 1.5%/y but was significant for men only. Survival for patients with oral cavity and other HNCs also increased in men only by 0.9%/y and 0.25%/y, respectively.
Oropharynx cancer, which is highly correlated with HPV infection, is increasing in incidence in Canada, with a decreasing age at diagnosis and an improvement in survival. This could have implications for screening strategies and treatment for oropharyngeal cancers in Canada.
本研究旨在调查过去十年加拿大头颈部癌症（HNC）的流行病学（发病率、诊断时年龄和生存率）变化。
对国家癌症数据登记处进行分析。
加拿大所有治疗头颈部癌症的医院机构。
利用加拿大癌症登记处的数据（1992-2007 年），作者根据人类乳头瘤病毒（HPV）的可能相关性将 HNC 分为 3 组：口咽（高度相关）、口腔（中度相关）和“其他”（下咽、喉和鼻咽），这些与 HPV 无关。他们计算了每个类别的年龄调整发病率、诊断时的中位年龄和生存率。
在研究期间，口咽肿瘤的发病率呈上升趋势（男性年增长率为 1.50%，女性为 0.80%），而口腔肿瘤的发病率则呈下降趋势（男性为 2.10%，女性为 0.40%），其他 HNC 也是如此（男性下降 3.0%，女性下降 1.9%）。口咽癌诊断时的中位年龄平均每年下降 0.23 岁。口腔癌没有变化，但其他 HNC 的年龄增加了 0.12 岁/年。口咽癌患者的生存率每年提高 1.5%，但仅对男性有显著影响。口腔癌和其他 HNC 患者的生存率也仅在男性中分别提高了 0.9%/年和 0.25%/年。
与 HPV 感染高度相关的口咽癌在加拿大的发病率呈上升趋势，诊断时的年龄呈下降趋势，生存率也有所提高。这可能对加拿大的口咽癌筛查策略和治疗产生影响。
