Bisof Vesna, Basić-Koretić Martina, Juretić Antonio, Krpan Ana Misir, Samardić Kristina Ruza, Rakusić Zoran, Santek Fedor, Krajina Zdenko, Podolski Paula, Sarić Nera, Crnjević Tanja Badovinac
Klinika za onkologiju, Medicinski fakultet Sveucilista u Zagrebu, KBC Zagreb.
Lijec Vjesn. 2011 Nov-Dec;133(11-12):384-8.
Multiple primary malignancies, metachronous or synchronous, in a single patient are relatively rare event with the increase of incidence in recent decades. The aim of this research is to study their incidence in patients hospitalized at the Division of Radiotherapy, Department of Oncology, University of Zagreb, School of medicine, University Hospital Centre Zagreb from 2003 to 2009. The incidence of multiple primary malignancies was 2.4%. Among 103 patients, 97 had two, and 6 three primary tumors. Eighty-three cases were metachronous, while 20 cases were synchronous malignancies. The frequency was higher in females than males and their age at diagnosis of tumors was younger than in males. The most common tumor combinations in males were: prostate cancer-digestive system malignancy (especially colorectal cancer) and viceversa, and hematological malignant tumors-digestive system malignancy; while in women there were: breast cancer-cancer of contralateral breast and hematological malignant tumors (especially lymphoma non Hodgkin)-breast cancer. The incidence of multiple primary malignancies is expected to increase due to the better screening programs for early detection of malignancies as well as considerable improvement in their treatment and longer life expectancy.
在同一患者中出现异时性或同时性的多种原发性恶性肿瘤是相对罕见的事件，近几十年来其发病率有所上升。本研究的目的是研究2003年至2009年期间在萨格勒布大学医学院肿瘤学系放射治疗科、萨格勒布大学医院中心住院患者中此类肿瘤的发病率。多种原发性恶性肿瘤的发病率为2.4%。在103例患者中，97例有两种原发性肿瘤，6例有三种原发性肿瘤。83例为异时性肿瘤，20例为同时性恶性肿瘤。女性的发病率高于男性，且其肿瘤诊断时的年龄比男性小。男性中最常见的肿瘤组合为：前列腺癌 - 消化系统恶性肿瘤（尤其是结直肠癌）及反之，以及血液系统恶性肿瘤 - 消化系统恶性肿瘤；而女性中则为：乳腺癌 - 对侧乳腺癌，以及血液系统恶性肿瘤（尤其是非霍奇金淋巴瘤） - 乳腺癌。由于恶性肿瘤早期检测的筛查项目更好、治疗有显著改善以及预期寿命延长，多种原发性恶性肿瘤的发病率预计将会上升。
