Diplock A T
Division of Biochemistry, United Medical School, University of London, Guy's Hospital, U.K.
Med Oncol Tumor Pharmacother. 1990;7(2-3):193-8. doi: 10.1007/BF02988548.
There are excellent theoretical reasons why the mineral nutrients selenium, manganese, copper and zinc, known as the antioxidant minerals, may be involved in the prevention of cancer aetiogenesis. The biochemistry is discussed of the part played by the antioxidant minerals, in the wider context of the other dietary antioxidants vitamins A, E and C, and beta carotene, in preventing tissue damage caused by activated metabolites of oxygen. The likely part played by these oxygen metabolites is described and a detailed review given of the evidence that suggests a role for antioxidant minerals, notably selenium, in preventing carcinogenesis in a range of animal models. There follows a summary of the emerging epidemiological evidence that suggests clearly that low selenium intake is a risk factor in the aetiology of human cancer.
有充分的理论依据表明，被称为抗氧化矿物质的硒、锰、铜和锌等矿物质营养素可能参与预防癌症的病因形成。本文讨论了抗氧化矿物质在更广泛的其他膳食抗氧化剂（维生素A、E、C和β-胡萝卜素）背景下所起的作用，这些抗氧化剂可预防由活性氧代谢产物引起的组织损伤。描述了这些氧代谢产物可能发挥的作用，并详细综述了一系列动物模型中表明抗氧化矿物质（尤其是硒）在预防癌症发生中起作用的证据。接下来是新兴流行病学证据的总结，这些证据清楚地表明低硒摄入是人类癌症病因中的一个风险因素。
