Department of Child Health Care, Children's Hospital Affiliated to Zhejiang University School of Medicine, Hangzhou, China.
BMC Public Health. 2012 Feb 14;12:126. doi: 10.1186/1471-2458-12-126.
Recent studies have suggested that vitamin D deficiency in children is widespread. But the vitamin D status of Chinese children is seldom investigated. The objective of the present study was to survey the serum levels of 25-hydroxyvitamin D [25(OH)D] in more than 6,000 children aged 1 month to 16 years in Hangzhou (latitude: 30°N), the capital of Zhejiang Province, southeast China.
The children aged 1 month to 16 years who came to the child health care department of our hospital, the children's hospital affiliated to Zhejiang university school of medicine, for health examination were taken blood for 25(OH) D measurement. Serum 25(OH) D levels were determined by direct enzyme-linked immunosorbent assay and categorized as < 25, < 50, and < 75 nmol/L.
A total of 6,008 children aged 1 month to 16 years participated in this cross-sectional study. All the subjects were divided into subgroups according to their age: 0-1y, 2-5y, 6-11y and 12-16y representing infancy, preschool, school age and adolescence stages respectively. The highest mean level of serum 25(OH)D was found in the 0-1y stage (99 nmol/L) and the lowest one was found in 12-16y stage (52 nmol/L). Accordingly, the prevalence of serum 25(OH)D levels of < 75 nmol/L and < 50 nmol/L were at the lowest among infants (33.6% and 5.4% respectively) and rose to the highest among adolescents (89.6% and 46.4% respectively). The mean levels of serum 25(OH)D and the prevalence of vitamin D deficiency changed according to seasons. In winter and spring, more than 50% of school age children and adolescents had a 25(OH)D level at < 50 nmol/L. If the threshold is changed to < 75 nmol/L, all of the adolescents (100%) had low 25(OH)D levels in winter and 93.7% school age children as well.
The prevalence of vitamin D deficiency and insufficiency among children in Hangzhou Zhejiang province is high, especially among children aged 6-16 years. We suggest that the recommendation for vitamin D supplementation in Chinese children should be extended to adolescence.
最近的研究表明，儿童维生素 D 缺乏症较为普遍。但是，中国儿童的维生素 D 状况很少被调查。本研究的目的是调查中国东南部浙江省省会杭州市 1 个月至 16 岁 6000 多名儿童的血清 25-羟维生素 D [25(OH)D]水平。
来我院儿童保健科、浙江大学医学院附属儿童医院体检的 1 个月至 16 岁儿童采集血液进行 25(OH)D 检测。采用直接酶联免疫吸附法测定血清 25(OH)D 水平，< 25、< 50 和< 75 nmol/L 为分类。
共有 6008 名 1 个月至 16 岁的儿童参与了这项横断面研究。根据年龄将所有受试者分为亚组：0-1y、2-5y、6-11y 和 12-16y，分别代表婴儿期、学龄前、学龄期和青春期。血清 25(OH)D 水平最高的是 0-1y 组（99 nmol/L），最低的是 12-16y 组（52 nmol/L）。因此，血清 25(OH)D< 75 nmol/L 和< 50 nmol/L 的发生率在婴儿期最低（分别为 33.6%和 5.4%），在青春期最高（分别为 89.6%和 46.4%）。血清 25(OH)D 水平的均值和维生素 D 缺乏症的发生率随季节而变化。在冬春两季，50%以上的学龄期儿童和青少年的 25(OH)D 水平< 50 nmol/L。如果将阈值改为< 75 nmol/L，则所有青少年（100%）在冬季和 93.7%的学龄儿童中均存在低 25(OH)D 水平。
浙江省杭州市儿童维生素 D 缺乏和不足的患病率较高，尤其是 6-16 岁儿童。我们建议将中国儿童补充维生素 D 的建议扩展到青春期。
