Medical College of Georgia, Department of Pediatrics, Georgia Prevention Institute, 1120 15th St, HS-1640, Augusta, GA 30912, USA.
Pediatrics. 2010 Jun;125(6):1104-11. doi: 10.1542/peds.2009-2055. Epub 2010 May 3.
The objectives were to characterize the vitamin D status of black and white adolescents residing in the southeastern United States (latitude: approximately 33 degrees N) and to investigate relationships with adiposity.
Plasma 25-hydroxyvitamin D levels were measured with liquid chromatography-tandem mass spectroscopy for 559 adolescents 14 to 18 years of age (45% black and 49% female). Fat tissues, physical activity, and cardiovascular fitness also were measured.
The overall prevalences of vitamin D insufficiency (<75 nmol/L) and deficiency (< or = 50 nmol/L) were 56.4% and 28.8%, respectively. Black versus white subjects had significantly lower plasma 25-hydroxyvitamin D levels in every season (winter, 35.9 + or - 2.5 vs 77.4 + or - 2.7 nmol/L; spring, 46.4 + or - 3.5 vs 101.3 + or - 3.5 nmol/L; summer, 50.7 + or - 4.0 vs 104.3 + or - 4.0 nmol/L; autumn, 54.4 + or - 4.0 vs 96.8 + or - 2.7 nmol/L). With adjustment for age, gender, race, season, height, and sexual maturation, there were significant inverse correlations between 25-hydroxyvitamin D levels and all adiposity measurements, including BMI percentile (P = .02), waist circumference (P < .01), total fat mass (P < .01), percentage of body fat (P < .01), visceral adipose tissue (P = .015), and subcutaneous abdominal adipose tissue (P = .039). There were significant positive associations between 25-hydroxyvitamin D levels and vigorous physical activity (P < .01) and cardiovascular fitness (P = .025).
Low vitamin D status is prevalent among adolescents living in a year-round sunny climate, particularly among black youths. The relationships between 25-hydroxyvitamin D levels, adiposity, physical activity, and fitness seem to be present in adolescence.
本研究旨在描述美国东南部（纬度约 33 度）黑人和白人青少年的维生素 D 状态，并探讨其与肥胖的关系。
本研究对 559 名 14 至 18 岁的青少年（45%为黑人，49%为女性）进行了液相色谱-串联质谱法测量血浆 25-羟维生素 D 水平。同时还测量了脂肪组织、身体活动和心血管健康状况。
维生素 D 不足（<75nmol/L）和缺乏（<50nmol/L）的总体患病率分别为 56.4%和 28.8%。在每个季节，黑人青少年的血浆 25-羟维生素 D 水平均显著低于白人青少年（冬季：35.9±2.5 与 77.4±2.7 nmol/L；春季：46.4±3.5 与 101.3±3.5 nmol/L；夏季：50.7±4.0 与 104.3±4.0 nmol/L；秋季：54.4±4.0 与 96.8±2.7 nmol/L）。调整年龄、性别、种族、季节、身高和性成熟度后，25-羟维生素 D 水平与所有肥胖测量值均呈显著负相关，包括 BMI 百分位数（P=0.02）、腰围（P<0.01）、总脂肪量（P<0.01）、体脂百分比（P<0.01）、内脏脂肪组织（P=0.015）和腹部皮下脂肪组织（P=0.039）。25-羟维生素 D 水平与剧烈身体活动（P<0.01）和心血管健康（P=0.025）呈显著正相关。
在一个全年阳光充足的气候环境中生活的青少年中，维生素 D 状态普遍较低，尤其是黑人青少年。25-羟维生素 D 水平与肥胖、身体活动和健康之间的关系似乎在青少年时期就已经存在。
