Laboratory of Pediatric Research, Children's Hospital of Wujiang District, Suzhou, 215234, Jiangsu, People's Republic of China.
Department of Clinical Laboratory, Children's Hospital of Wujiang District, Suzhou, 215234, Jiangsu, People's Republic of China.
Sci Rep. 2024 May 31;14(1):12562. doi: 10.1038/s41598-024-62305-7.
Vitamin D deficiency and insufficiency pose global public health challenges, yet research on serum vitamin D levels in the 0-17-year-old age group in southeastern China remains limited. This study aimed to fill this gap by investigating serum 25(OH)D levels in children in the region aged 0-17 years, contributing crucial data for understanding vitamin D nutritional status. Liquid chromatography‒mass spectrometry/mass spectrometry (LC‒MS/MS) technology was used. Vitamin D testing was integrated into routine diagnostic procedures for 11,116 children in Wujiang District, Suzhou City. Among the 0-17-year age group, comprising 6348 boys and 4768 girls, the prevalence of serum 25(OH)D deficiency and insufficiency was 21.4% and 31.0%, respectively. The median serum 25(OH)D concentration was 29.72 ng/mL (21.84-39.84 ng/mL) in boys compared to 28.48 ng/mL (20.65-39.23 ng/mL) in girls. Seasonal variations were observed, with median serum 25(OH)D concentrations of 29.02 ng/mL (20.73-39.72 ng/mL) in spring, 28.79 ng/mL (21.53-39.37 ng/mL) in summer, 30.12 ng/mL (22.00-39.70 ng/mL) in autumn, and 28.58 ng/mL (19.97-39.46 ng/mL) in winter. Statistically significant differences were noted in the serum 25(OH)D levels during autumn and winter. In conclusion, the rate of adequate vitamin D levels in local children was 47.5%, revealing a relatively high prevalence of vitamin D deficiency (21.4%) and insufficiency (31.0%), especially during the post-preschool period. Advocating for vitamin D supplementation in children is crucial for ensuring adequate vitamin D support.
维生素 D 缺乏和不足对全球公共健康构成挑战，但中国东南部 0-17 岁人群血清维生素 D 水平的研究仍然有限。本研究旨在通过调查该地区 0-17 岁儿童的血清 25(OH)D 水平，填补这一空白，为了解维生素 D 营养状况提供重要数据。采用液相色谱-质谱/质谱（LC-MS/MS）技术。将维生素 D 检测纳入苏州市吴江区 11116 名儿童的常规诊断程序。在 0-17 岁年龄组中，包括 6348 名男孩和 4768 名女孩，血清 25(OH)D 缺乏和不足的患病率分别为 21.4%和 31.0%。男孩的血清 25(OH)D 中位数浓度为 29.72ng/mL（21.84-39.84ng/mL），女孩为 28.48ng/mL（20.65-39.23ng/mL）。观察到季节性变化，春季血清 25(OH)D 中位数浓度为 29.02ng/mL（20.73-39.72ng/mL），夏季为 28.79ng/mL（21.53-39.37ng/mL），秋季为 30.12ng/mL（22.00-39.70ng/mL），冬季为 28.58ng/mL（19.97-39.46ng/mL）。秋季和冬季血清 25(OH)D 水平存在统计学差异。总之，当地儿童充足维生素 D 水平的比例为 47.5%，表明维生素 D 缺乏（21.4%）和不足（31.0%）的患病率相对较高，尤其是在学龄前。提倡儿童补充维生素 D 对于确保充足的维生素 D 支持至关重要。
