Li Bin, Wang Jianhong, Xu Jialie, Xie Jianying, Liu Quanyong, Yang Chenxi, Zhang Zhengmao
Department of orthopaedics, Yuhuan people's hospital, Taizhou, Zhejiang, China.
Front Endocrinol (Lausanne). 2025 Apr 30;16:1450924. doi: 10.3389/fendo.2025.1450924. eCollection 2025.
Given the global prevalence of vitamin D deficiency, this study examines the association between serum 25-hydroxyvitamin D (25(OH)D) levels and lipid profiles, including total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG).
In a cross-sectional analysis at the Yuhuan People's Hospital Physical Examination Center, 1535 asymptomatic individuals underwent anthropometric assessment and blood sampling. Serum 25(OH)D levels were quantified by a chemiluminescent immunoassay, while lipid parameters were evaluated by an enzymatic method on a fully automated analyzer.
The mean serum 25(OH)D level of the participants was 49.6 ± 15.3 nmol/L, with 54.7% demonstrating vitamin D deficiency. Female participants had significantly lower mean 25(OH)D levels (46.2 ± 13.7 nmol/L) than males (54.1 ± 16.0 nmol/L, P < 0.001). After adjustment for age and BMI, multivariate ordinal logistic analysis revealed a 1.71-fold higher dyslipidemia-associated risk of vitamin D deficiency in the population (OR=1.71, 95% CI=1.07-2.79), more pronounced in females(OR=2.84, 95% CI=1.17-8.09) compared to males (OR=1.44, 95% CI=0.82-2.58). Notably, vitamin D deficiency was significantly associated with elevated LDL-C levels in females (OR=5.17, 95% CI=1.47-32.96), in contrast to males.
This study highlights a significant association between 25(OH)D deficiency and an increased risk of dyslipidemia, especially in females, highlighting the importance of considering gender-specific risk factors in the management of 25(OH)D deficiency.
鉴于维生素D缺乏在全球的普遍存在，本研究探讨血清25-羟基维生素D（25(OH)D）水平与血脂谱之间的关联，血脂谱包括总胆固醇、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）和甘油三酯（TG）。
在玉环市人民医院体检中心进行的一项横断面分析中，1535名无症状个体接受了人体测量评估和血液采样。血清25(OH)D水平通过化学发光免疫分析法进行定量，而血脂参数则在全自动分析仪上通过酶法进行评估。
参与者的平均血清25(OH)D水平为49.6±15.3nmol/L，54.7%的人存在维生素D缺乏。女性参与者的平均25(OH)D水平（46.2±13.7nmol/L）显著低于男性（54.1±16.0nmol/L，P<0.001）。在调整年龄和体重指数后，多变量有序逻辑分析显示，人群中维生素D缺乏与血脂异常相关风险高1.71倍（OR=1.71，95%CI=1.07-2.79），女性（OR=2.84，95%CI=1.17-8.09）比男性（OR=1.44，95%CI=0.82-2.58）更明显。值得注意的是，与男性相比，维生素D缺乏与女性LDL-C水平升高显著相关（OR=5.17，95%CI=1.47-32.96）。
本研究强调了25(OH)D缺乏与血脂异常风险增加之间的显著关联，尤其是在女性中，突出了在管理25(OH)D缺乏时考虑性别特异性风险因素的重要性。
