Department of Psychology, National University of Ireland, Maynooth, Co. Kildare, Ireland.
Schizophr Res. 2012 May;137(1-3):91-6. doi: 10.1016/j.schres.2012.01.017. Epub 2012 Feb 12.
Language impairments are a well established finding in patients with schizophrenia and in individuals at-risk for psychosis. A growing body of research has revealed shared risk factors between individuals with psychotic-like experiences (PLEs) from the general population and patients with schizophrenia. In particular, adolescents with PLEs have been shown to be at an increased risk for later psychosis. However, to date there has been little information published on electrophysiological correlates of language comprehension in this at-risk group. A 64 channel EEG recorded electrical activity while 37 (16 At-Risk; 21 Controls) participants completed the British Picture Vocabulary Scale (BPVS-II) receptive vocabulary task. The P300 component was examined as a function of language comprehension. The at-risk group were impaired behaviourally on receptive language and were characterised by a reduction in P300 amplitude relative to the control group. The results of this study reveal electrophysiological evidence for receptive language deficits in adolescents with PLEs, suggesting that the earliest neurobiological changes underlying psychosis may be apparent in the adolescent period.
语言障碍是精神分裂症患者和精神病高危人群的一个既定发现。越来越多的研究揭示了普通人群中具有类精神病体验（PLEs）的个体和精神分裂症患者之间存在共同的风险因素。特别是，具有 PLEs 的青少年后来患精神病的风险增加。然而，迄今为止，关于该高危人群语言理解的电生理相关性的信息很少。64 通道 EEG 记录了电活动，而 37 名（16 名高危；21 名对照）参与者完成了英国图片词汇量表（BPVS-II）接受性词汇任务。检查了 P300 成分作为语言理解的函数。高危组在接受性语言方面表现出行为障碍，其 P300 幅度相对于对照组减小。这项研究的结果揭示了青少年 PLEs 接受性语言缺陷的电生理证据，表明精神病潜在的最早神经生物学变化可能在青少年时期就已经出现。
