Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Medical School, Chicago, IL 60611, USA.
J Exp Med. 2012 Feb 13;209(2):211-5. doi: 10.1084/jem.20120162.
Cellular transformation is associated with the reprogramming of cellular pathways that control proliferation, survival, and metabolism. Among the metabolic changes exhibited by tumor cells is an increase in glucose metabolism and glucose dependence. It has been hypothesized that targeting glucose metabolism may provide a selective mechanism by which to kill cancer cells. In this minireview, we discuss the benefits that high levels of glycolysis provide for tumor cells, as well as several key enzymes required by cancer cells to maintain this high level of glucose metabolism. It is anticipated that understanding which metabolic enzymes are particularly critical for tumor cell proliferation and survival will identify novel therapeutic targets.
细胞转化与控制增殖、存活和代谢的细胞途径的重编程有关。肿瘤细胞表现出的代谢变化之一是葡萄糖代谢和葡萄糖依赖性增加。有人假设，靶向葡萄糖代谢可能提供一种选择性机制来杀死癌细胞。在这篇小综述中，我们讨论了高水平的糖酵解为肿瘤细胞提供的益处，以及癌细胞维持这种高水平葡萄糖代谢所需的几种关键酶。预计，了解哪些代谢酶对肿瘤细胞增殖和存活特别关键将确定新的治疗靶点。
