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J Nutr. 2011 Feb;141(2):207-13. doi: 10.3945/jn.110.130021. Epub 2010 Dec 22.
2
Dietary omega-3 fatty acid supplementation increases the rate of muscle protein synthesis in older adults: a randomized controlled trial.膳食ω-3 脂肪酸补充剂增加老年人肌肉蛋白质合成率:一项随机对照试验。
Am J Clin Nutr. 2011 Feb;93(2):402-12. doi: 10.3945/ajcn.110.005611. Epub 2010 Dec 15.
3
OMEGA, a randomized, placebo-controlled trial to test the effect of highly purified omega-3 fatty acids on top of modern guideline-adjusted therapy after myocardial infarction.OMEGA 试验:一项随机、安慰剂对照试验,旨在测试高纯度 ω-3 脂肪酸在心肌梗死后现代指南调整治疗基础上的疗效。
Circulation. 2010 Nov 23;122(21):2152-9. doi: 10.1161/CIRCULATIONAHA.110.948562. Epub 2010 Nov 8.
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Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trial.二十二碳六烯酸补充剂与阿尔茨海默病认知能力下降:一项随机试验。
JAMA. 2010 Nov 3;304(17):1903-11. doi: 10.1001/jama.2010.1510.
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Effect of DHA supplementation during pregnancy on maternal depression and neurodevelopment of young children: a randomized controlled trial.孕期补充 DHA 对产妇抑郁和幼儿神经发育的影响:一项随机对照试验。
JAMA. 2010 Oct 20;304(15):1675-83. doi: 10.1001/jama.2010.1507.
6
n-3 fatty acids and cardiovascular events after myocardial infarction.n-3 脂肪酸与心肌梗死后的心血管事件。
N Engl J Med. 2010 Nov 18;363(21):2015-26. doi: 10.1056/NEJMoa1003603. Epub 2010 Aug 28.
7
Omega-3 fatty acid supplementation improves vascular function and reduces inflammation in obese adolescents.ω-3 脂肪酸补充剂可改善肥胖青少年的血管功能并减轻炎症。
Atherosclerosis. 2010 Oct;212(2):580-5. doi: 10.1016/j.atherosclerosis.2010.06.046. Epub 2010 Jul 21.
8
Effects of docosahexaenoic acid supplementation during pregnancy on gestational age and size at birth: randomized, double-blind, placebo-controlled trial in Mexico.孕期补充二十二碳六烯酸对胎龄及出生体重的影响:墨西哥的一项随机、双盲、安慰剂对照试验
Food Nutr Bull. 2010 Jun;31(2 Suppl):S108-16. doi: 10.1177/15648265100312S203.
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Effects of seal oil and tuna-fish oil on platelet parameters and plasma lipid levels in healthy subjects.海豹油和金枪鱼鱼油对健康受试者血小板参数及血脂水平的影响。
Lipids. 2010 Aug;45(8):669-81. doi: 10.1007/s11745-010-3450-z. Epub 2010 Jul 23.
10
Eicosapentaenoic acid (EPA) from highly concentrated n-3 fatty acid ethyl esters is incorporated into advanced atherosclerotic plaques and higher plaque EPA is associated with decreased plaque inflammation and increased stability.二十碳五烯酸(EPA)来源于高度浓缩的 n-3 脂肪酸乙酯,可被整合入动脉粥样硬化斑块中,且斑块中 EPA 含量越高,斑块炎症越低,稳定性越高。
Atherosclerosis. 2010 Sep;212(1):252-9. doi: 10.1016/j.atherosclerosis.2010.05.022. Epub 2010 May 20.

ω-3 脂肪酸 EPA 和 DHA:终生健康益处。

Omega-3 fatty acids EPA and DHA: health benefits throughout life.

机构信息

Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY, USA.

出版信息

Adv Nutr. 2012 Jan;3(1):1-7. doi: 10.3945/an.111.000893. Epub 2012 Jan 5.

DOI:10.3945/an.111.000893
PMID:22332096
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3262608/
Abstract

Omega-3 [(n-3)] fatty acids have been linked to healthy aging throughout life. Recently, fish-derived omega-3 fatty acids EPA and DHA have been associated with fetal development, cardiovascular function, and Alzheimer's disease. However, because our bodies do not efficiently produce some omega-3 fatty acids from marine sources, it is necessary to obtain adequate amounts through fish and fish-oil products. Studies have shown that EPA and DHA are important for proper fetal development, including neuronal, retinal, and immune function. EPA and DHA may affect many aspects of cardiovascular function including inflammation, peripheral artery disease, major coronary events, and anticoagulation. EPA and DHA have been linked to promising results in prevention, weight management, and cognitive function in those with very mild Alzheimer's disease.

摘要

ω-3(n-3)脂肪酸与终生健康老龄化有关。最近,来源于鱼类的 ω-3 脂肪酸 EPA 和 DHA 与胎儿发育、心血管功能和阿尔茨海默病有关。然而,由于我们的身体不能有效地从海洋来源中产生一些 ω-3 脂肪酸,因此有必要通过鱼类和鱼油产品获得足够的量。研究表明,EPA 和 DHA 对胎儿的正常发育很重要,包括神经元、视网膜和免疫功能。EPA 和 DHA 可能影响心血管功能的许多方面,包括炎症、外周动脉疾病、主要冠状动脉事件和抗凝。EPA 和 DHA 与预防、体重管理和轻度阿尔茨海默病患者的认知功能方面的有希望的结果有关。