老年临床队列中脑脊液β淀粉样蛋白和tau蛋白水平的波动
Cerebrospinal fluid Aβ and tau level fluctuation in an older clinical cohort.
作者信息
Moghekar Abhay, Goh Joshua, Li Ming, Albert Marilyn, O'Brien Richard J
机构信息
Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
出版信息
Arch Neurol. 2012 Feb;69(2):246-50. doi: 10.1001/archneurol.2011.732.
OBJECTIVE
To determine whether cerebrospinal fluid (CSF) biomarkers for Alzheimer disease fluctuate significantly over time in a cohort of older, mildly symptomatic individuals.
DESIGN
Biomarker validation in a clinical cohort.
SETTING
University hospital inpatient unit.
PARTICIPANTS
Ten patients admitted for CSF drainage for diagnostic purposes.
MAIN OUTCOME MEASURES
The CSF levels of Aβ1-40, Aβ1-42, tau, and phosphorylated tau on threonine 181 (p-tau(181)) were measured every 6 hours for 24 or 36 hours.
RESULTS
The mean coefficient of variation values for each biomarker assessed in our 10 patients were 5.5% (95% CI, 3.8%-10.0%) for Aβ1-42, 12.2% (9.0%-24.2%) for Aβ1-40, 8.2% (5.7%-15.1%) for total tau, and 11.9% (8.5%-23.0%) for p-tau(181). These values are only slightly higher than the variability in the assay. In addition, no significant circadian fluctuation in any Alzheimer disease biomarker was observed given the limitations of our sampling frequency.
CONCLUSION
In a cohort of elderly patients, little fluctuation in the levels of important Alzheimer disease biomarkers in lumbar CSF is seen as a function of time.
目的
确定在一组年龄较大、症状较轻的个体中，阿尔茨海默病的脑脊液生物标志物是否随时间显著波动。
设计
临床队列中的生物标志物验证。
地点
大学医院住院部。
参与者
因诊断目的接受脑脊液引流的10名患者。
主要观察指标
在24或36小时内，每6小时测量一次脑脊液中Aβ1-40、Aβ1-42、tau蛋白以及苏氨酸181位点磷酸化tau蛋白（p-tau(181)）的水平。
结果
在我们的10名患者中，评估的每种生物标志物的平均变异系数值分别为：Aβ1-42为5.5%（95%CI，3.8%-10.0%），Aβ1-40为12.2%（9.0%-24.2%），总tau蛋白为8.2%（5.7%-15.1%），p-tau(181)为11.9%（8.5%-23.0%）。这些值仅略高于检测中的变异性。此外，鉴于我们采样频率的局限性，未观察到任何阿尔茨海默病生物标志物有显著的昼夜波动。
结论
在一组老年患者中，腰椎脑脊液中重要的阿尔茨海默病生物标志物水平随时间变化波动很小。
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