Malenkova E N, Sobol' I L, Aleshina L V, Fedotov V P
Vopr Onkol. 1979;25(5):26-8.
Under study was the hypophysis influence on the growth of human melanoma explants, cultivated in the abdominal cavity of mice and rats. The heterotransplants growth was compared in intact and hypophysectomized animals exposed to ACTH, and also the effect of the murine hypophysis explanted into the adjacent chamber compartments on the melanoma explants growth was investigated. The growth was assessed by a square area of the explants growth zones. ACTH and the hypophysis explanted were found to render a stimulating effect on the growth of tumor heterotransplants. Hypophysectomy in rats would suppress the growth of all melanoma explants under investigation. When injecting ACTH into hypophysectomized animals the growth of melanoma heterotransplants in the chambers does not differ from that in control series.
研究了垂体对在小鼠和大鼠腹腔中培养的人黑色素瘤外植体生长的影响。比较了完整动物和接受促肾上腺皮质激素（ACTH）的垂体切除动物中异种移植的生长情况，还研究了植入相邻腔室的小鼠垂体对外植体生长的影响。通过外植体生长区域的面积评估生长情况。发现ACTH和植入的垂体对肿瘤异种移植的生长有刺激作用。大鼠垂体切除会抑制所有研究中的黑色素瘤外植体的生长。向垂体切除的动物注射ACTH时，腔室内黑色素瘤异种移植的生长与对照系列无差异。
