Rijnmond Care Group, Nursing Home Slingedael, Center for Korsakoff and Psychogeriatry, Rotterdam, The Netherlands.
Am J Addict. 2012 Mar-Apr;21(2):104-10. doi: 10.1111/j.1521-0391.2011.00199.x.
We present a descriptive, retrospective study of initial symptoms, comorbidity, and alcohol withdrawal in 73 alcoholic patients with subsequent Korsakoff syndrome. In 25/73 (35%) of the patients the classic triad of Wernicke's encephalopathy with ocular symptoms, ataxia and confusion, was found. In at least 6/35 (17%) of the initial deliria (95% confidence interval: 10-25%) we observed no other underlying causes, thus excluding other somatic causes, medication, (recent) alcohol withdrawal, or intoxication. We suggest that these deliria may have been representing Wernicke's encephalopathy. A high frequency (15%) of diabetics may reflect a contributing factor of diabetes mellitus in the evolution of the Wernicke-Korsakoff syndrome.
我们对 73 例随后发生柯萨科夫综合征的酒精性患者的首发症状、合并症和酒精戒断进行了描述性、回顾性研究。在 73 例患者中的 25 例（35%）中发现了具有眼部症状、共济失调和意识混乱的典型韦尼克脑病三联征。在至少 6/35 例（95%置信区间：10-25%）初始谵妄中，我们未观察到其他潜在病因，从而排除了其他躯体病因、药物、（近期）酒精戒断或中毒。我们认为这些谵妄可能代表韦尼克脑病。较高的糖尿病发病率（15%）可能反映了糖尿病在韦尼克-柯萨科夫综合征发展过程中的一个促成因素。
