Laboratory of Molecular Pathology, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi, China.
Lipids Health Dis. 2012 Feb 14;11:25. doi: 10.1186/1476-511X-11-25.
Considerable arguments remain regarding the diverse biological activities of polyunsaturated fatty acids (PUFA). One of the most interesting but controversial dietary approaches focused on the diverse function of dihomo-dietary γ-linolenic acid (DGLA) in anti-inflammation and anti-proliferation diseases, especially for cancers. This strategy is based on the ability of DGLA to interfere in cellular lipid metabolism and eicosanoid (cyclooxygenase and lipoxygenase) biosynthesis. Subsequently, DGLA can be further converted by inflammatory cells to 15-(S)-hydroxy-8,11,13-eicosatrienoic acid and prostaglandin E1 (PGE1). This is noteworthy because these compounds possess both anti-inflammatory and anti-proliferative properties. PGE1 could also induce growth inhibition and differentiation of cancer cells. Although the mechanism of DGLA has not yet been elucidated, it is significant to anticipate the antitumor potential benefits from DGLA.
关于多不饱和脂肪酸（PUFA）的多种生物学活性，仍存在大量争议。其中最有趣但最具争议的饮食方法之一是关注二同型-膳食 γ-亚麻酸（DGLA）在抗炎和抗增殖疾病中的多种功能，尤其是癌症。这种策略基于 DGLA 干扰细胞脂质代谢和类二十烷酸（环加氧酶和脂加氧酶）生物合成的能力。随后，炎症细胞可以将 DGLA 进一步转化为 15-（S）-羟基-8,11,13-二十碳三烯酸和前列腺素 E1（PGE1）。这一点值得注意，因为这些化合物具有抗炎和抗增殖特性。PGE1 还可以诱导癌细胞的生长抑制和分化。尽管 DGLA 的机制尚未阐明，但预期 DGLA 具有抗肿瘤潜在益处是很重要的。
