Okada Ichirou, Shirahata Atsushi, Soda Hitoshi, Saitou Mitsuo, Kigawa Gaku, Nemoto Hiroshi, Sanada Yutaka, Hibi Kenji
Dept. of Gastroenterological Surgery, Showa University, Japan.
Gan To Kagaku Ryoho. 2012 Feb;39(2):231-5.
We analyzed the relationship between Onodera's prognostic nutritional index(PNI), classified by serum albumin level, lymphocyte level, and clinicopathological features, in 46 patients with unresectable or recurrent colorectal cancer being treated with chemotherapy.Onodera 's PNI was distributed between 29.7 and 56.1(average 45.4±6.8 ).Onodera 's PNI showed a significant correlation with performance status and surgery before chemotherapy(p=0.002 and 0.002, respectively).Next, all patients were divided into two groups according to their Onodera's PNI values, based on the receiver operator characteristic curve.We found that Onodera's PNI showed a significant correlation with overall survival times(median survival time, 548 days(Onodera's PNI<47.8 ), 902 days(Onodera's PNI≥47.8 ), p=0.00065 ).This PNI could be a prognostic factor and a very useful objective screening tool for assessing the nutritional condition of those with unresectable or recurrent colorectal cancer being treated with chemotherapy.
我们分析了46例接受化疗的不可切除或复发性结直肠癌患者中，根据血清白蛋白水平、淋巴细胞水平分类的小野寺预后营养指数（PNI）与临床病理特征之间的关系。小野寺PNI分布在29.7至56.1之间（平均45.4±6.8）。小野寺PNI与化疗前的体能状态和手术情况显著相关（分别为p=0.002和0.002）。接下来，根据受试者工作特征曲线，将所有患者按小野寺PNI值分为两组。我们发现小野寺PNI与总生存时间显著相关（中位生存时间，548天（小野寺PNI<47.8），902天（小野寺PNI≥47.8），p=0.00065）。该PNI可能是一个预后因素，也是评估接受化疗的不可切除或复发性结直肠癌患者营养状况的非常有用的客观筛查工具。
