Department of Respiratory Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Shandong University, No. 324 Jingwuweiqi Road, Jinan, 250021, Shandong Province, People's Republic of China.
J Cancer Res Clin Oncol. 2013 Dec;139(12):2117-23. doi: 10.1007/s00432-013-1523-0. Epub 2013 Oct 23.
Nutritional status has been associated with long-time outcomes in cancer patients. We investigated whether the prognostic nutritional index (PNI), an indicator of nutritional status, affects overall survival in patients with malignant pleural mesothelioma (MPM).
We enrolled 121 patients with histologically confirmed MPM, who had successfully undergone biopsy by medical thoracoscopy in this study. Demographic, clinical and laboratory data were collected retrospectively. The PNI was calculated as 10× serum albumin value (g/dl) + 0.005 × total lymphocyte count (per mm(3)) in peripheral blood. Univariate and multivariate analyses were used to identify prognostic factors.
Mean pretreatment PNI was 44.6. PNI was significantly associated with age (P = 0.031), smoking habits (P = 0.039) and weight loss (P = 0.029). Survival analysis showed PNI to be an independent prognostic factor in MPM. Patients with lower PNIs (PNI < 44.6) had greater risk of death than those with higher PNIs (PNI ≥ 44.6; hazard ratio: 2.290; 95 % confidence interval: 1.415-3.706; P = 0.001). These analyses were adjusted for patient age, gender, smoking habits, dyspnea, chest pain, weight loss, primary site of tumor, histology, platinum-based systemic chemotherapy, hospital and stage.
Pretreatment PNI is a novel independent prognostic factor in MPM.
营养状况与癌症患者的长期预后相关。我们研究了营养状态指标预后营养指数（PNI）是否会影响恶性胸膜间皮瘤（MPM）患者的总生存。
我们纳入了 121 名经医疗胸腔镜活检病理证实为 MPM 的患者。回顾性收集了人口统计学、临床和实验室数据。PNI 是通过外周血中血清白蛋白值（g/dl）的 10 倍与总淋巴细胞计数（per mm(3)）的 0.005 倍相加计算得出。采用单因素和多因素分析来确定预后因素。
预处理前的平均 PNI 为 44.6。PNI 与年龄（P = 0.031）、吸烟习惯（P = 0.039）和体重减轻（P = 0.029）显著相关。生存分析显示 PNI 是 MPM 的独立预后因素。PNI 较低的患者（PNI < 44.6）死亡风险高于 PNI 较高的患者（PNI ≥ 44.6；风险比：2.290；95 %置信区间：1.415-3.706；P = 0.001）。这些分析是根据患者年龄、性别、吸烟习惯、呼吸困难、胸痛、体重减轻、肿瘤原发部位、组织学、铂类为基础的系统化疗、医院和分期进行调整的。
预处理 PNI 是 MPM 的一种新的独立预后因素。
