Park Chanhun, Nam Hee-Geun, Kim Pung-Ho, Mun Sungyong
Department of Chemical Engineering, Hanyang University, Seoul, Korea.
J Sep Sci. 2014 Jun;37(11):1215-21. doi: 10.1002/jssc.201400089. Epub 2014 Apr 13.
The removal of isoleucine from valine has been a key issue in the stage of valine crystallization, which is the final step in the valine production process in industry. To address this issue, a three-zone simulated moving-bed (SMB) process for the separation of valine and isoleucine has been developed previously. However, the previous process, which was based on a classical port-location mode, had some limitations in throughput and valine product concentration. In this study, a three-zone SMB process based on a modified port-location mode was applied to the separation of valine and isoleucine for the purpose of making a marked improvement in throughput and valine product concentration. Computer simulations and a lab-scale process experiment showed that the modified three-zone SMB for valine separation led to >65% higher throughput and >160% higher valine concentration compared to the previous three-zone SMB for the same separation.
在缬氨酸结晶阶段，从缬氨酸中去除异亮氨酸一直是一个关键问题，而缬氨酸结晶是工业缬氨酸生产过程的最后一步。为解决这一问题，之前已开发出一种用于分离缬氨酸和异亮氨酸的三区模拟移动床（SMB）工艺。然而，之前基于经典端口定位模式的工艺在通量和缬氨酸产物浓度方面存在一些局限性。在本研究中，为显著提高通量和缬氨酸产物浓度，一种基于改进端口定位模式的三区SMB工艺被应用于缬氨酸和异亮氨酸的分离。计算机模拟和实验室规模的工艺实验表明，与之前用于相同分离的三区SMB相比，改进后的用于缬氨酸分离的三区SMB通量提高了65%以上，缬氨酸浓度提高了160%以上。
